Vitamin K deficiency: Difference between revisions

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==Background==
=Background=
#Is cofactor for vit k dependent clotting factors 2, 7, 9, 10
#Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
##used by liver
##Used by liver
##fat soluble
##Fat soluble


==DDX (Deficiency)==
=Differential Diagnosis of Deficiency=
# Nutritional def
#Nutritional deficiency
# Malabsorption
#Malabsorption
##Since is fat soluble
#Cholestasis: since it is fat soluble and needs bile salts to be absorbed
# Cholestasis
##need bile salts to absorb vit k


==Treatment (Deficiency)==
=Treatment for Deficiency)=
#FFP
#Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
#Consider Vitamin K  
#Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off
##Takes 24hrs to affect & 2wk to wear off


==See Also==
=See Also=
*[[Warfarin (Coumadin) Reversal]]
*[[Warfarin (Coumadin) Reversal]]
*[[Coagulation Disorders]]
*[[Coagulation Disorders]]

Revision as of 19:05, 24 August 2013

Background

  1. Cofactor for vitamin K-dependent clotting factors II, VII, IX, X
    1. Used by liver
    2. Fat soluble

Differential Diagnosis of Deficiency

  1. Nutritional deficiency
  2. Malabsorption
  3. Cholestasis: since it is fat soluble and needs bile salts to be absorbed

Treatment for Deficiency)

  1. Fresh Frozen Plasma: 1ml contains 1U of each clotting factor
  2. Consider Vitamin K oral or IV (subcutaneous not recommended): will take up to 24 hours to work and up to 2 weeks to wear off

See Also