Acute generalized exanthematous pustulosis: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Background== *T-cell mediated rash with systemic features *>90% of cases attributable to a medication (usually an antibiotic) *Mortality rate of ~5% ==Clinical Features...") |
ClaireLewis (talk | contribs) |
||
| Line 7: | Line 7: | ||
[[File:Acute generalized exanthematous pustulosis.png|thumb|]] | [[File:Acute generalized exanthematous pustulosis.png|thumb|]] | ||
*Onset 1-5 days after starting causative medication | *Onset 1-5 days after starting causative medication | ||
*Rash: | *[[Rash]]: | ||
**Large areas of edematous erythema with numerous small, non-follicular pustules | **Large areas of edematous erythema with numerous small, non-follicular pustules | ||
**Predominantly affects main body folds and upper trunk, but can involve face | **Predominantly affects main body folds and upper trunk, but can involve face | ||
**NO mucous membrane involvement | **NO mucous membrane involvement (in contrast to SJS/TEN) | ||
*Systemic findings: | *Systemic findings: | ||
**Fever | **[[Fever]] | ||
** | **[[Leukocytosis]], specifically neutrophilia | ||
**+/- Facial swelling | **+/- Facial swelling | ||
**+/- Hepatitis | **+/- [[Hepatitis]] | ||
**+/- Eosinophilia | **+/- [[Eosinophilia]] | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Revision as of 05:06, 11 December 2016
Background
- T-cell mediated rash with systemic features
- >90% of cases attributable to a medication (usually an antibiotic)
- Mortality rate of ~5%
Clinical Features
- Onset 1-5 days after starting causative medication
- Rash:
- Large areas of edematous erythema with numerous small, non-follicular pustules
- Predominantly affects main body folds and upper trunk, but can involve face
- NO mucous membrane involvement (in contrast to SJS/TEN)
- Systemic findings:
- Fever
- Leukocytosis, specifically neutrophilia
- +/- Facial swelling
- +/- Hepatitis
- +/- Eosinophilia
Differential Diagnosis
- Erythema Multiforme
- Stevens-Johnson syndrome and toxic epidermal necrolysis
- Staphylococcal scalded skin syndrome
- Erythroderma
- Toxic Shock Syndrome
- Drug eruption
- DRESS syndrome
Evaluation
- Clinical diagnosis
- CBC
- BMP
- LFTs
Management
- Stop inciting agent
- IVF- treat similar to fluid resuscitation in burns
- Wound care, infection control
Disposition
- Admit