Non-Hodgkin's lymphoma: Difference between revisions
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==Background== | ==Background== | ||
* | *Can originate in lymphatic system or any organ in the body | ||
*Occurs in children > | *Occurs in children >5 years old | ||
*Immunosuppression (e.g. [[HIV]], [[crohn's]], chemotherapy) is a risk factor | |||
==Clinical Features== | ==Clinical Features== | ||
*[[Lymphadenopathy]] | *[[Lymphadenopathy]] | ||
*Hepatosplenomegaly | *Hepatosplenomegaly | ||
*"B" symptoms | *"B" symptoms ([[fever]], night sweats, weight loss) | ||
*GI | *GI: [[GI bleed]], [[intussusception]], [[nausea/vomiting]] | ||
*Signs/symptoms of complications: | |||
**[[Superior vena cava syndrome]] | |||
**[[Pleural effusion]], [[pericardial effusion]] | |||
**[[Malignant cord compression]] | |||
**[[Tumor lysis syndrome]] (rare in absence of active treatment) | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==Evaluation== | ==Evaluation== | ||
*CBC | *CBC | ||
* | *BMP, LFTs, uric acid | ||
*[[CXR]] | *[[CXR]] | ||
==Management== | ==Management== | ||
See management sections of specific complications: | |||
*[[Superior vena cava syndrome]] | |||
*Superior vena cava syndrome | *[[Pleural effusion]], [[pericardial effusion]] | ||
*Pleural | *[[Malignant cord compression]] | ||
* | *[[Tumor lysis syndrome]] | ||
*[[Neutropenic fever]] | |||
*[[Nausea/vomiting]] | |||
*[[GI bleeding]], [[intussusception]] | |||
==See Also== | ==See Also== | ||
Revision as of 01:37, 11 December 2016
Background
- Can originate in lymphatic system or any organ in the body
- Occurs in children >5 years old
- Immunosuppression (e.g. HIV, crohn's, chemotherapy) is a risk factor
Clinical Features
- Lymphadenopathy
- Hepatosplenomegaly
- "B" symptoms (fever, night sweats, weight loss)
- GI: GI bleed, intussusception, nausea/vomiting
- Signs/symptoms of complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome (rare in absence of active treatment)
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Evaluation
- CBC
- BMP, LFTs, uric acid
- CXR
Management
See management sections of specific complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome
- Neutropenic fever
- Nausea/vomiting
- GI bleeding, intussusception