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| == Acute Myeloid Leukemia ==
| | #REDIRECT[[Leukemia]] |
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| === Background ===
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| *aka Acute myelogenous leukemia or non-lymphocytic leukemia
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| *Most common acute leukemia in adulst (around 80% of cases)
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| *65yo is median age of diagnosis, Male:Female 5:3
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| *characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)
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| === Diagnosis ===
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| *Presents with anemia, neutropenia, thrombocytopenia,
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| *weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia
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| === Work-Up ===
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| *CXR
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| *CBC with peripheral smear
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| *Chem7, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
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| *LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
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| *Get extra purple top for flow cytometry, especially if transfusion needed
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| === Treatment ===
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| *Aggressive IV hydration
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| *If febrile, complete cultures and broad spectrum antibiotics
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| *Manage Complications
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| **(see DIC)
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| **(see Leukostasis)
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| **(see Tumor Lysis Syndrome)
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| == Acute Lymphocytic Leukemia ==
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| === Background ===
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| *characterized by proliferation of immature lymphoblast( >20% in periphery)
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| *less than 20% of acute leukemias in adults, most common form in children (see also Acute Leukemia Peds)
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| *Highest incidence in 7th decade of life
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| === Diagnosis ===
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| *Lymphocytosis, neutropenia, anemia, thrombocytopenia,
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| *Lymphadenopathy, hepatosplenomegaly
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| *CNS and testes involvement common
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| === DDX ===
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| *Hodgkin and non-Hodgkin lymphomas
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| === Work-Up ===
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| *Aggressive IV hydration
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| *If febrile, complete cultures and broad spectrum antibiotics
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| *Manage Complications
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| **(see DIC)
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| **(see Leukostasis)
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| **(see Tumor Lysis Syndrome)
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| == Source ==
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| Uptodate & MKSAP15
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| [[Category:Heme/Onc]] | |
