Flunisolide: Difference between revisions
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*Hypersensitivity to drug/class | *Hypersensitivity to drug/class | ||
*Status asthmaticus | *Status asthmaticus | ||
*Asthma,acute | *[[Asthma]], acute | ||
*Avoid abrupt withdrawal | *Avoid abrupt withdrawal | ||
*Bronchospasm, acute | *Bronchospasm, acute | ||
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*Cataracts | *Cataracts | ||
*Osteoporosis | *Osteoporosis | ||
*erythema multiforme | *[[erythema multiforme]] | ||
===Common=== | ===Common=== | ||
*URI | *[[URI]] | ||
*Headache | *[[Headache]] | ||
*Nausea/vomiting | *[[Nausea/vomiting]] | ||
*Dyspepsia | *[[Dyspepsia]] | ||
*UTI | *[[UTI]] | ||
*Abdominal pain | *[[Abdominal pain]] | ||
*Chest pain | *[[Chest pain]] | ||
*Infection | *Infection | ||
*Neck pain | *[[Neck pain]] | ||
*Diarrhea | *[[Diarrhea]] | ||
*Candidiasis, oral | *Candidiasis, oral | ||
*Edema | *Edema | ||
*Myalgia | *Myalgia | ||
*Dizziness | *[[Dizziness]] | ||
*Insomnia | *Insomnia | ||
*Voice changes | *Voice changes | ||
*Conjunctivitis | *[[Conjunctivitis]] | ||
*Ear pain | *Ear pain | ||
*Taste changes | *Taste changes | ||
*Dysmenorrhea | *Dysmenorrhea | ||
*Vaginitis | *[[Vaginitis]] | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 13:58, 10 November 2016
Administration
- Type: Corticosteroid
- Dosage Forms: 80mcg/spray
- Routes of Administration: Inhalation
- Common Trade Names: Aerospan
Adult Dosing
- Inhalation: 2-4 puffs BID
- Max: 640 mcg/day
Pediatric Dosing
- 6-11 yo: 1-2 puffs BID
- Max: 320 mcg/day
- >12 yo: 2-4 puffs BID
- Max: 640 mcg/day
Special Populations
- Pregnancy Rating: D; Possible risk of fetal adrenal suppression; Low risk of teratogenicity
- Lactation risk: L3; Safety unknown
Renal Dosing
- Adult: Not Defined
- Pediatric: Not Defined
Hepatic Dosing
- Adult: Not Defined
- Pediatric: Not Defined
Contraindications
- Allergy to class/drug
- Hypersensitivity to drug/class
- Status asthmaticus
- Asthma, acute
- Avoid abrupt withdrawal
- Bronchospasm, acute
Adverse Reactions
Serious
- Bronchospasm
- Adrenal suppression
- Hypercorticism
- Growth suppression (peds pts)
- Glaucoma
- Cataracts
- Osteoporosis
- erythema multiforme
Common
- URI
- Headache
- Nausea/vomiting
- Dyspepsia
- UTI
- Abdominal pain
- Chest pain
- Infection
- Neck pain
- Diarrhea
- Candidiasis, oral
- Edema
- Myalgia
- Dizziness
- Insomnia
- Voice changes
- Conjunctivitis
- Ear pain
- Taste changes
- Dysmenorrhea
- Vaginitis
Pharmacology
- Half-life: 1.3-1.7 hr
- Metabolism: Liver; CYP450: 3A4 substrate
- Excretion: Urine <1%
Mechanism of Action
Exact mechanism unknown. Inhibits multiple inflammatory cytokines and produces multiple glucocorticoid and mineralocorticoid effects.