Enalaprilat

Administration

• Type: ACE inhibitor
• Dosage Forms:
• Routes of Administration: IV
• Common Trade Names: Vasotec

Adult Dosing

• 1.25-5mg IV q6h
• 0.625mg IV initially, with repeated dose of 0.625mg if inadequate response for the following patients:
  • CrCl <30
  • Severe volume or salt depletion, recent HD, or concomitant diuretic use
  • CHF

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk minimal

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug
• Angioedema history (ACEi-induced, hereditary, or idiopathic)

Adverse Reactions

Serious

• Myocardial infarction
• Liver failure
• Angioedema

Common

• Hyperkalemia
• Nausea
• Headache

Pharmacology

• Half-life: ~11h
• Metabolism:
• Excretion: Renal. Dialyzable

Mechanism of Action

• Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II.