https://wikem.org/w/index.php?action=history&feed=atom&title=Zoledronate 2026-04-16T00:45:40Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Zoledronate&diff=225728&oldid=prev 2019-08-24T21:10:47Z

<p>Created page with &quot;==Administration== *Type: Bisphosphonate *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *4mg IV once, may repeat in 7d ==Pediatric Dosin...&quot;</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Bisphosphonate<br /> *Dosage Forms:<br /> *Routes of Administration: IV<br /> *Common Trade Names: <br /> <br /> ==Adult Dosing==<br /> *4mg IV once, may repeat in 7d<br /> <br /> ==Pediatric Dosing==<br /> ''Safety/efficacy not established''<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Pregnancy category D<br /> <br /> ===Lactation risk===<br /> *No information available, avoid use or breastfeeding<br /> <br /> ===Renal Dosing===<br /> *Adult:<br /> **CrCl 50-60 mL/min: 3.5 mg<br /> **CrCl 40-49 mL/min: 3.3 mg<br /> **CrCl 30-39 mL/min: 3 mg<br /> **CrCl &lt;30 mL/min: Not recommended<br /> <br /> ===Hepatic Dosing===<br /> ''Safety/efficacy not established''<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Hypocalcemia<br /> *Severe renal impairment (CrCl &lt;35 mL/min or evidence of acute renal impairment)<br /> **Rehydrate hypovolemic patients prior to administration<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Hypocalcemia<br /> *Bronchoconstriction if aspirin-sensitive asthma<br /> *Osteonecrosis (usually of jaw)<br /> *Acquired fanconi syndrome<br /> *Hypotension<br /> <br /> ===Common===<br /> *Bone pain, arthralgia<br /> *Nausea/vomiting, constipation, diarrhea<br /> *Fever<br /> *Fatigue, insomnia, anxiety<br /> *Anemia<br /> *Dyspnea<br /> *Headache, dizziness<br /> *UTI<br /> *Hypophosphatemia, hypokalemia, hypomagnesemia<br /> *Rash<br /> <br /> ==Pharmacology==<br /> *Half-life: 146h<br /> *Metabolism: Not metabolized<br /> *Excretion: Urinary<br /> <br /> ==Mechanism of Action==<br /> *Acts on osteoclasts to inhibit bone resorption<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> https://reference.medscape.com/drug/reclast-zometa-zoledronic-acid-342858#10<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

ClaireLewis