Vasculitis syndromes - Revision history

Rossdonaldson1: /* Background */

2023-08-02T18:19:39Z

Background

← Older revision		Revision as of 18:19, 2 August 2023
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	==Background==		==Background==
			[[File:Histopathology of giant cell arteritis.png\|thumb\|[[Giant cell arteritis]] on histopathology.]]
	*Heterogenous group of disorders, clinico-pathologic process characterized by inflammation within walls of blood vessels, compromise of vessel lumen, and resulting ischemia		*Heterogenous group of disorders, clinico-pathologic process characterized by inflammation within walls of blood vessels, compromise of vessel lumen, and resulting ischemia
	*Presentation varies greatly depending on etiology and specific vessels affected		*Presentation varies greatly depending on etiology and specific vessels affected

Rossdonaldson1: /* Background */

2023-08-02T17:50:21Z

Background

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 *Presentation varies greatly depending on etiology and specific vessels affected
 *Classification by size of vessels predominantly involved
-*Large-vessel:
-**[[Takayasu arteritis]]
+{{Primary Vasculitis DDX}}
 ==Clinical Features==

Elcatracho: /* See Also */

2021-03-08T19:49:37Z

ClaireLewis at 16:03, 18 October 2019

2019-10-18T16:03:56Z

← Older revision		Revision as of 16:03, 18 October 2019
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	*Small-vessel:		*Small-vessel:
	**[[Henoch-Schönlein purpura]]		**[[Henoch-Schönlein purpura]]
	**ANCA-associated vasculitides: [[~~granulomatosis~~ with polyangiitis]], [[~~eosinophilic~~ granulomatosis with polyangiitis]]~~, microscopic~~ polyangiitis		**ANCA-associated vasculitides:
			***[[Granulomatosis with polyangiitis]] (Wegner's)
			***[[Eosinophilic granulomatosis with polyangiitis]] (Churg-Strauss)
			***Microscopic polyangiitis
	**Cutaneous leukocytoclastic angiitis (“hypersensitivity vasculitis”)		**Cutaneous leukocytoclastic angiitis (“hypersensitivity vasculitis”)
	**Essential cryoglobulinemia, cryoglobulinemic vasculitis due to [[hepatitis C]]		**Essential cryoglobulinemia, cryoglobulinemic vasculitis due to [[hepatitis C]]
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	*Secondary vasculitides and other/miscellaneous		*Secondary vasculitides and other/miscellaneous
	**Drug-induced vasculitis		**Drug-induced vasculitis
	**Serum sickness		**[[Serum sickness]]
	**Vasculitis associated with other rheumatic diseases		**Vasculitis associated with other rheumatic diseases (e.g. [[SLE]])

	==Clinical Features==		==Clinical Features==
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	*Bruits		*Bruits
	*[[Aortic regurgitation]]		*[[Aortic regurgitation]]
	*Sudden blindness (giant cell arteritis)		*Sudden [[vision loss\|blindness]] (giant cell arteritis)

	===Medium Vessel Vasculitis===		===Medium Vessel Vasculitis===
	*Cutaneous nodules, livedo reticularis		*Cutaneous nodules, livedo reticularis
	*Ulcers		*Ulcers
	*Digital gangrene		*Digital [[gangrene]]
	*Mononeuritis multiplex (asynchronous/asymmetric peripheral neuropathy)		*Mononeuritis multiplex (asynchronous/asymmetric peripheral neuropathy)
	*Microaneurysms		*Microaneurysms

	===Small Vessel Vasculitis===		===Small Vessel Vasculitis===
	*[[Purpura]], urticaria, cutaneous necrotizing granulomas, splinter hemorrhages		*[[Purpura]], [[urticaria]], cutaneous necrotizing granulomas, splinter hemorrhages
	*[[Uveitis]] (ciliary spasm, visual changes, limbic redness), [[scleritis]]/[[episcleritis]] (ocular pain, photophobia)		*[[Uveitis]] (ciliary spasm, visual changes, limbic redness), [[scleritis]]/[[episcleritis]] (ocular pain, photophobia)
	*[[Glomerulonephritis]] ([[hematuria]], [[proteinuria]]		*[[Glomerulonephritis]] ([[hematuria]], [[proteinuria]]
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	*Treat underlying illness, if known		*Treat underlying illness, if known
	*Manage critical complications: see treatment section of [[diffuse alveolar hemorrhage]], [[acute limb ischemia]], [[Kawasaki]]		*Manage critical complications: see treatment section of [[diffuse alveolar hemorrhage]], [[acute limb ischemia]], [[Kawasaki]]
	*For primary vasculitides, this will likely involve an ~~immunosupressive~~ agent, such as:		*For primary vasculitides, this will likely involve an immunosuppressive agent, such as:
	**[[Prednisone]]/[[Methylprednisolone]]		**[[Prednisone]]/[[Methylprednisolone]]
	**[[Cyclophosphamide]], [[methotrexate]], [[azathioprine]]		**[[Cyclophosphamide]], [[methotrexate]], [[azathioprine]]

Rossdonaldson1: /* Differential Diagnosis */

2019-07-18T20:37:59Z

Differential Diagnosis

← Older revision		Revision as of 20:37, 18 July 2019
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	==Differential Diagnosis==		==Differential Diagnosis==
			{{Purpura DDX}}

	==Evaluation==		==Evaluation==

ClaireLewis: Created page with "==Background== *Heterogenous group of disorders, clinico-pathologic process characterized by inflammation within walls of blood vessels, compromise of vessel lumen, and resul..."

2016-11-13T04:22:36Z

Created page with "==Background== *Heterogenous group of disorders, clinico-pathologic process characterized by inflammation within walls of blood vessels, compromise of vessel lumen, and resul..."

New page

==Background==
*Heterogenous group of disorders, clinico-pathologic process characterized by inflammation within walls of blood vessels, compromise of vessel lumen, and resulting ischemia
*Presentation varies greatly depending on etiology and specific vessels affected
*Classification by size of vessels predominantly involved
*Large-vessel:
**[[Takayasu arteritis]]
**[[Giant cell arteritis]] (temporal arteritis)
*Medium-vessel:
**[[Kawasaki disease]]
**[[Polyarteritis nodosa]]
**[[Thromboangiitis obliterans]] (Buerger disease)
**Primary angiitis of the central nervous system
*Small-vessel:
**[[Henoch-Schönlein purpura]]
**ANCA-associated vasculitides: [[granulomatosis with polyangiitis]], [[eosinophilic granulomatosis with polyangiitis]], microscopic polyangiitis
**Cutaneous leukocytoclastic angiitis (“hypersensitivity vasculitis”)
**Essential cryoglobulinemia, cryoglobulinemic vasculitis due to [[hepatitis C]]
**[[Behcet's disease]]
*Secondary vasculitides and other/miscellaneous
**Drug-induced vasculitis
**Serum sickness
**Vasculitis associated with other rheumatic diseases

==Clinical Features==
*[[Fever]]
*[[Arthralgia]]s/[[arthritis]]
*Malaise, fatigue, weight loss

===Large Vessel Vasculitis===
*Limb claudication
*Asymmetric blood pressures
*Diminished or absent peripheral pulses
*Bruits
*[[Aortic regurgitation]]
*Sudden blindness (giant cell arteritis)

===Medium Vessel Vasculitis===
*Cutaneous nodules, livedo reticularis
*Ulcers
*Digital gangrene
*Mononeuritis multiplex (asynchronous/asymmetric peripheral neuropathy)
*Microaneurysms

===Small Vessel Vasculitis===
*[[Purpura]], urticaria, cutaneous necrotizing granulomas, splinter hemorrhages
*[[Uveitis]] (ciliary spasm, visual changes, limbic redness), [[scleritis]]/[[episcleritis]] (ocular pain, photophobia)
*[[Glomerulonephritis]] ([[hematuria]], [[proteinuria]]
*[[Hemoptysis]], [[Diffuse alveolar hemorrhage]]

==Differential Diagnosis==

==Evaluation==
*Workup dependent on presentation, likely to include at least CBC, ESR, BMP, UA

==Management==
*Treat underlying illness, if known
*Manage critical complications: see treatment section of [[diffuse alveolar hemorrhage]], [[acute limb ischemia]], [[Kawasaki]]
*For primary vasculitides, this will likely involve an immunosupressive agent, such as:
**[[Prednisone]]/[[Methylprednisolone]]
**[[Cyclophosphamide]], [[methotrexate]], [[azathioprine]]
**[[Rituximab]]
*May consider [[plasmapheresis]] for severe or rapidly progressive

==Disposition==

==See Also==

==External Links==

==References==
<references/>

[[Category:Rheumatology]] [[Category:Vascular]]

← Older revision		Revision as of 19:49, 8 March 2021
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	==See Also==		==See Also==
			*[[Immunocompromised antibiotics]]
			*[[Biologic immunomodulators]]

	==External Links==		==External Links==