Unfractionated heparin reversal - Revision history

Ostermayer: /* Management */

2022-07-06T15:06:23Z

Management

← Older revision		Revision as of 15:06, 6 July 2022
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	*[[Protamine]]		*[[Protamine]]
	**Only indicated for major bleeding (0.2% of patients develop severe anaphylaxis)		**Only indicated for major bleeding (0.2% of patients develop severe anaphylaxis)
	**Give 1mg IV for every 100 units of UFH infused in the prior 3hr		{{Heparin reversal}}
	**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period
	**Because half-life is short (7 min) may require second treatment
	*[[hemorrhage\|Massive bleed]]		*[[hemorrhage\|Massive bleed]]
	**[[Cryoprecipitate]] (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)		**[[Cryoprecipitate]] (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)

ClaireLewis: /* References */

2019-10-01T19:03:52Z

References

← Older revision		Revision as of 19:03, 1 October 2019
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	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
			[[Category:Pharmacology]]

ClaireLewis at 19:03, 1 October 2019

2019-10-01T19:03:39Z

← Older revision		Revision as of 19:03, 1 October 2019
Line 1:		Line 1:
	==Background==		==Background==
	*Managed according to clinical severity, NOT PTT value		*Managed according to clinical severity of bleeding, NOT PTT value
	**Heparin-associated bleeding is not always reflected by a supratherapeutic PTT		**Heparin-associated bleeding is not always reflected by a supratherapeutic PTT

	==~~Clinical Features~~==		==Indications==
			*Significant bleeding while on [[heparin] drip
	~~==Differential Diagnosis==~~

	~~==Workup==~~

	==Management==		==Management==
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	**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period		**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period
	**Because half-life is short (7 min) may require second treatment		**Because half-life is short (7 min) may require second treatment
	*Massive bleed		*[[hemorrhage\|Massive bleed]]
	**Cryoprecipitate (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)		**[[Cryoprecipitate]] (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)

	==Disposition==		==Disposition==

ClaireLewis: /* Management */

2016-10-19T16:14:37Z

Management

← Older revision		Revision as of 16:14, 19 October 2016
Line 12:		Line 12:
	*Stop transfusion		*Stop transfusion
	*Observation alone may be appropriate in less severe cases		*Observation alone may be appropriate in less severe cases
	*Protamine		*[[Protamine]]
	**Only indicated for major bleeding (0.2% of patients develop severe anaphylaxis)		**Only indicated for major bleeding (0.2% of patients develop severe anaphylaxis)
	**Give 1mg IV for every 100 units of UFH infused in the prior 3hr		**Give 1mg IV for every 100 units of UFH infused in the prior 3hr
Line 18:		Line 18:
	**Because half-life is short (7 min) may require second treatment		**Because half-life is short (7 min) may require second treatment
	*Massive bleed		*Massive bleed
	**Cryoprecipitate (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)		**Cryoprecipitate (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)

	==Disposition==		==Disposition==

Neil.m.young: Text replacement - "==Sources==" to "==References=="

2016-06-26T16:02:27Z

Text replacement - "==Sources==" to "==References=="

← Older revision		Revision as of 16:02, 26 June 2016
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	==External Links==		==External Links==

	==~~Sources~~==		==References==
	<references/>		<references/>

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Ostermayer: Text replacement - " pts" to " patients"

2016-06-21T16:50:01Z

Text replacement - " pts" to " patients"

← Older revision		Revision as of 16:50, 21 June 2016
Line 13:		Line 13:
	*Observation alone may be appropriate in less severe cases		*Observation alone may be appropriate in less severe cases
	*Protamine		*Protamine
	**Only indicated for major bleeding (0.2% of ~~pts~~ develop severe anaphylaxis)		**Only indicated for major bleeding (0.2% of patients develop severe anaphylaxis)
	**Give 1mg IV for every 100 units of UFH infused in the prior 3hr		**Give 1mg IV for every 100 units of UFH infused in the prior 3hr
	**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period		**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period

Rossdonaldson1 at 08:51, 31 January 2015

2015-01-31T08:51:52Z

← Older revision		Revision as of 08:51, 31 January 2015
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	==Sources==		==Sources==
	<references/>		<references/>

			[[Category:Heme/Onc]]

Rossdonaldson1: /* See Also */

2015-01-17T23:12:41Z

Rossdonaldson1: Rossdonaldson1 moved page Heparin reversal to Unfractionated heparin reversal

2015-01-17T23:10:42Z

Rossdonaldson1 moved page Heparin reversal to Unfractionated heparin reversal

← Older revision	Revision as of 23:10, 17 January 2015
(No difference)

Rossdonaldson1: Created page with "==Background== *Managed according to clinical severity, NOT PTT value **Heparin-associated bleeding is not always reflected by a supratherapeutic PTT ==Clinical Features== =..."

2015-01-17T22:59:51Z

Created page with "==Background== *Managed according to clinical severity, NOT PTT value **Heparin-associated bleeding is not always reflected by a supratherapeutic PTT ==Clinical Features== =..."

New page

==Background==
*Managed according to clinical severity, NOT PTT value
**Heparin-associated bleeding is not always reflected by a supratherapeutic PTT

==Clinical Features==

==Differential Diagnosis==

==Workup==

==Management==
*Stop transfusion
*Observation alone may be appropriate in less severe cases
*Protamine
**Only indicated for major bleeding (0.2% of pts develop severe anaphylaxis)
**Give 1mg IV for every 100 units of UFH infused in the prior 3hr
**Give slowly over 1-3min; do not exceed 50mg in any 10 minute period
**Because half-life is short (7 min) may require second treatment
*Massive bleed
**Cryoprecipitate (10 U IV), then [[FFP]] (& platelets, aminocaproic acid infusion if nec)

==Disposition==

==See Also==

==External Links==

==Sources==
<references/>

← Older revision		Revision as of 23:12, 17 January 2015
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	==See Also==		==See Also==
			*[[Coagulopathy (Main)]]
			*[[Unfractionated heparin]]

	==External Links==		==External Links==