Stone heart - Revision history

ClaireLewis at 17:00, 26 September 2019

2019-09-26T17:00:49Z

← Older revision		Revision as of 17:00, 26 September 2019
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	==Background==		==Background==
	*Administration of intravenous calcium thought to be contraindicated in patients with [[Digoxin Toxicity\|~~Digitalis Toxicity~~]] based on 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>		*Administration of intravenous [[calcium chloride\|calcium]] thought to be contraindicated in patients with [[Digoxin Toxicity\|digitalis toxicity]] based on 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>
	*It was theorized in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-[[troponin]] C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>		*It was theorized in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-[[troponin]] C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>
	*Excess calcium may also predispose to arrhythmias by adversely affecting re-polarization		*Excess calcium may also predispose to [[arrhythmias]] by adversely affecting re-polarization

	==Current Literature==		==Current Literature==

SLuckettG: /* Current Literature */

2019-02-28T17:43:53Z

Current Literature

← Older revision		Revision as of 17:43, 28 February 2019
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	==Current Literature==		==Current Literature==
	*Patients with digoxin toxicity who ~~were~~ given calcium ~~did~~ not have a statistically significant increase in mortality (22% versus 20%)<ref>Levine M, Nikkanen H, Pallin DJ. The effects of intravenous calcium in patients with digoxin toxicity. J Emerg Med. 2011 Jan;40(1):41-6 [http://www.emergencymedicine.utoronto.ca/Assets/EmergeMed%20Digital%20Assets/event/Journal%20Club/The%20Effects%20of%20Intravenous%20Calcium%20in%20Patients%20with%20Digoxin%20Toxicity.pdf FullText]</ref>		*Patients with digoxin toxicity who given calcium do not have a statistically significant increase in mortality (22% versus 20%)<ref>Levine M, Nikkanen H, Pallin DJ. The effects of intravenous calcium in patients with digoxin toxicity. J Emerg Med. 2011 Jan;40(1):41-6 [http://www.emergencymedicine.utoronto.ca/Assets/EmergeMed%20Digital%20Assets/event/Journal%20Club/The%20Effects%20of%20Intravenous%20Calcium%20in%20Patients%20with%20Digoxin%20Toxicity.pdf FullText]</ref>
	*A 2003 case report describes positive benefit from treating hyperkalemia in the setting of digitalis toxicity<ref>Van Deusen SK, et al. Treatment of hyperkalemia in a patient with unrecognized digitalis toxicity J Toxicol Clin Toxicol 2003;41:373-376.</ref>		*A 2003 case report describes positive benefit from treating hyperkalemia in the setting of digitalis toxicity<ref>Van Deusen SK, et al. Treatment of hyperkalemia in a patient with unrecognized digitalis toxicity J Toxicol Clin Toxicol 2003;41:373-376.</ref>

SLuckettG: /* Background */

2019-02-28T17:43:18Z

Background

← Older revision		Revision as of 17:43, 28 February 2019
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	==Background==		==Background==
	*~~IV administration~~ of intravenous calcium ~~was~~ thought to be contraindicated in patients with [[Digoxin Toxicity\|Digitalis Toxicity]] ~~since a~~ 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>		*Administration of intravenous calcium thought to be contraindicated in patients with [[Digoxin Toxicity\|Digitalis Toxicity]] based on 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>
	*It was theorized ~~and described~~ in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-[[troponin]] C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>		*It was theorized in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-[[troponin]] C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>
	*~~The excess~~ calcium may also predispose to arrhythmias by adversely affecting re-polarization		*Excess calcium may also predispose to arrhythmias by adversely affecting re-polarization

	==Current Literature==		==Current Literature==

Rossdonaldson1: Text replacement - "troponin " to "troponin "

2016-12-04T14:47:15Z

Text replacement - "troponin " to "troponin "

← Older revision		Revision as of 14:47, 4 December 2016
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	==Background==		==Background==
	*IV administration of intravenous calcium was thought to be contraindicated in patients with [[Digoxin Toxicity\|Digitalis Toxicity]] since a 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>		*IV administration of intravenous calcium was thought to be contraindicated in patients with [[Digoxin Toxicity\|Digitalis Toxicity]] since a 1936 case report<ref>Bower JO ,Mengle HAK. The additive effect of calcium and digitalis. JAMA 1936;106(14):1151–1153.</ref>
	*It was theorized and described in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-troponin C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>		*It was theorized and described in case report that calcium may cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-[[troponin]] C binding in the presence of Na/K channel blockade by Digoxin<ref>Erickson CP, Olson KR. Case files of the medical toxicology fellowship of the California poison control system-San Francisco: calcium plus digoxin-more taboo than toxic? J Med Toxicol. 2008;4(1):33-39. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550094/pdf/13181_2009_Article_BF03160949.pdf FullText]</ref>
	*The excess calcium may also predispose to arrhythmias by adversely affecting re-polarization		*The excess calcium may also predispose to arrhythmias by adversely affecting re-polarization

Ostermayer: Text replacement - "Category:Tox" to "Category:Toxicology"

2016-03-22T16:23:10Z

Text replacement - "Category:Tox" to "Category:Toxicology"

← Older revision		Revision as of 16:23, 22 March 2016
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	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:Cardiology]][[Category:~~Tox~~]]		[[Category:Cardiology]][[Category:Toxicology]]

Ostermayer: Text replacement - "Category:Cards" to "Category:Cardiology"

2016-03-22T13:52:59Z

Text replacement - "Category:Cards" to "Category:Cardiology"

← Older revision		Revision as of 13:52, 22 March 2016
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	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:~~Cards~~]][[Category:Tox]]		[[Category:Cardiology]][[Category:Tox]]

Rossdonaldson1: /* See Also */

2015-09-09T04:46:57Z

Rossdonaldson1: /* Sources */

2015-09-09T04:46:44Z

Sources

← Older revision		Revision as of 04:46, 9 September 2015
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	==~~Sources~~==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:Cards]][[Category:Tox]]		[[Category:Cards]][[Category:Tox]]

Rossdonaldson1: Rossdonaldson1 moved page Stone Heart to Stone heart

2015-09-09T04:46:30Z

Rossdonaldson1 moved page Stone Heart to Stone heart

← Older revision	Revision as of 04:46, 9 September 2015
(No difference)

Ostermayer at 02:24, 9 September 2015

2015-09-09T02:24:27Z

← Older revision		Revision as of 02:24, 9 September 2015
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	==See Also==		==See Also==
	*[[Digitalis Toxicity]]		*[[Digitalis Toxicity]]
			*[[Digoxin]]
	*[[Electrolyte Abnormalities (Main)\| Electrolyte Abnormalities]]		*[[Electrolyte Abnormalities (Main)\| Electrolyte Abnormalities]]

← Older revision		Revision as of 04:46, 9 September 2015
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	*[[Digoxin]]		*[[Digoxin]]
	*[[Electrolyte Abnormalities (Main)\| Electrolyte Abnormalities]]		*[[Electrolyte Abnormalities (Main)\| Electrolyte Abnormalities]]


	==References==		==References==