Sepsis (main) - Revision history

Danbot: Strip excess bold text - keep only critical safety emphasis

2026-03-22T09:22:59Z

Strip excess bold text - keep only critical safety emphasis

Danbot: Add SOFA_Calculator to page

2026-03-21T16:31:43Z

Add SOFA_Calculator to page

← Older revision		Revision as of 16:31, 21 March 2026
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	{{SIRS_Calculator}}		{{SIRS_Calculator}}

			{{SOFA_Calculator}}

	==External Links==		==External Links==

Danbot: Move calculators to own section with header (visible in TOC), expanded, before External Links

2026-03-21T15:05:59Z

Move calculators to own section with header (visible in TOC), expanded, before External Links

@@ Line 244: / Line 244: @@
 *Admit, likely to step-down or ICU
 *SSC 2021 suggests admitting patients with sepsis or septic shock who require ICU care '''within 6 hours''' of identification<ref name="SSC2021"/>
 ==External Links==
@@ Line 262: / Line 267: @@
 {{reflist|2}}
 [[Category:ID]]
 [[Category:Critical Care]]

Danbot: Add SIRS Criteria calculator (collapsible)

2026-03-21T13:43:14Z

Add SIRS Criteria calculator (collapsible)

← Older revision		Revision as of 13:43, 21 March 2026
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	<div class="mw-collapsible-content">		<div class="mw-collapsible-content">
	{{QSOFA_Calculator}}		{{QSOFA_Calculator}}
			</div>
			</div>

			<div class="mw-collapsible mw-collapsed" style="border:1px solid #aaa; padding:5px; margin-top:10px;">
			<div style="font-weight:bold;">📊 SIRS Criteria Calculator [show]</div>
			<div class="mw-collapsible-content">
			{{SIRS_Calculator}}
	</div>		</div>
	</div>		</div>
	[[Category:ID]]		[[Category:ID]]
	[[Category:Critical Care]]		[[Category:Critical Care]]

Danbot: Add qSOFA (Quick SOFA) calculator (collapsible)

2026-03-21T13:43:13Z

Add qSOFA (Quick SOFA) calculator (collapsible)

← Older revision		Revision as of 13:43, 21 March 2026
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	{{reflist\|2}}		{{reflist\|2}}


			<div class="mw-collapsible mw-collapsed" style="border:1px solid #aaa; padding:5px; margin-top:10px;">
			<div style="font-weight:bold;">📊 qSOFA (Quick SOFA) Calculator [show]</div>
			<div class="mw-collapsible-content">
			{{QSOFA_Calculator}}
			</div>
			</div>
	[[Category:ID]]		[[Category:ID]]
	[[Category:Critical Care]]		[[Category:Critical Care]]

Danbot: Convert vasopressor and steroid dosing to MedicationDose templates for SMW integration

2026-03-20T22:18:22Z

Convert vasopressor and steroid dosing to MedicationDose templates for SMW integration

← Older revision		Revision as of 22:18, 20 March 2026
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	'''Options:'''		'''Options:'''
	*~~'''[[~~Norepinephrine~~]]''' (~~0.1-1 mcg/kg/min, typical ~~starting dose~~ 5-20 mcg/min) ~~— '''~~1st line~~'''~~<ref>[[EBQ:SOAP II Trial]]</ref><ref name="SSC2021"/>		*{{MedicationDose\|drug=Norepinephrine\|dose=0.1-1 mcg/kg/min (typical start 5-20 mcg/min)\|route=IV drip\|context=1st line vasopressor\|indication=Sepsis (main)\|population=Adult}} <ref>[[EBQ:SOAP II Trial]]</ref><ref name="SSC2021"/>
	*~~'''[[~~Vasopressin~~]]''' (~~0.03 units/min fixed dose) ~~— '''~~2nd line~~'''~~, added to norepinephrine ~~rather than escalating NE above 0.25-0.5 mcg/kg/min~~<ref name="SSC2021"/>		*{{MedicationDose\|drug=Vasopressin\|dose=0.03 units/min (fixed dose)\|route=IV drip\|context=2nd line vasopressor, added to norepinephrine\|indication=Sepsis (main)\|population=Adult}}<ref name="SSC2021"/>
	**SSC 2021 suggests adding vasopressin '''before''' epinephrine		**SSC 2021 suggests adding vasopressin '''before''' epinephrine
	**May reduce the risk of atrial fibrillation compared to catecholamine-only regimens<ref>McIntyre WF, Um KJ, Alhazzani W, et al. Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock. JAMA. 2018;319(18):1889.</ref>		**May reduce the risk of atrial fibrillation compared to catecholamine-only regimens<ref>McIntyre WF, Um KJ, Alhazzani W, et al. Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock. JAMA. 2018;319(18):1889.</ref>
	*~~'''[[~~Epinephrine~~]]''' (~~1-20 mcg/min~~) — '''~~3rd line~~''', added to norepinephrine + vasopressin if MAP target not achieved~~<ref name="SSC2021"/>		*{{MedicationDose\|drug=Epinephrine\|dose=1-20 mcg/min\|route=IV drip\|context=3rd line vasopressor\|indication=Sepsis (main)\|population=Adult}}<ref name="SSC2021"/>
	*'''[[Dopamine]]''' — should be used hesitantly and only in highly selected patients (e.g. patients with low risk of tachyarrhythmias and absolute or relative bradycardia)		*'''[[Dopamine]]''' — should be used hesitantly and only in highly selected patients (e.g. patients with low risk of tachyarrhythmias and absolute or relative bradycardia)
	**Do '''not''' use low-dose dopamine for renal protection		**Do '''not''' use low-dose dopamine for renal protection
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	===[[Vasopressors\|Inotropes]]===		===[[Vasopressors\|Inotropes]]===
	*~~'''[[~~Dobutamine~~]]''' (~~2-20 mcg/kg/min) may be added if:		*{{MedicationDose\|drug=Dobutamine\|dose=2-20 mcg/kg/min\|route=IV drip\|context=Inotrope for sepsis-related myocardial dysfunction\|indication=Sepsis (main)\|population=Adult}} may be added if:
	**Myocardial dysfunction as suggested by elevated cardiac filling pressures and low cardiac output		**Myocardial dysfunction as suggested by elevated cardiac filling pressures and low cardiac output
	**Ongoing signs of hypoperfusion despite achieving adequate intravascular volume and adequate MAP		**Ongoing signs of hypoperfusion despite achieving adequate intravascular volume and adequate MAP
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	**'''Suggests''' corticosteroids for adults with septic shock (conditional recommendation, low certainty)		**'''Suggests''' corticosteroids for adults with septic shock (conditional recommendation, low certainty)
	**'''Recommends against''' high-dose/short-duration corticosteroids (>400 mg/day hydrocortisone equivalent for <3 days) (strong recommendation, moderate certainty)		**'''Recommends against''' high-dose/short-duration corticosteroids (>400 mg/day hydrocortisone equivalent for <3 days) (strong recommendation, moderate certainty)
	*'''Dosing:''' [[Hydrocortisone~~]] 200~~ mg IV ~~daily, divided~~ q6h (50 mg ~~q6h~~) ~~or as continuous infusion~~		*'''Dosing:''' {{MedicationDose\|drug=Hydrocortisone\|dose=50 mg IV q6h (200 mg/day)\|route=IV\|context=Stress dose steroids for septic shock\|indication=Sepsis (main)\|population=Adult}}
	*Do '''not''' administer steroids for treatment of sepsis in the '''absence of shock'''		*Do '''not''' administer steroids for treatment of sepsis in the '''absence of shock'''
	*Stress dose steroids are associated with faster time to shock resolution and faster ICU discharge<ref>Venkatesh B, Finfer S, Cohen J, et al; ADRENAL Trial Investigators. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med. 2018;378(9):797-808.</ref>		*Stress dose steroids are associated with faster time to shock resolution and faster ICU discharge<ref>Venkatesh B, Finfer S, Cohen J, et al; ADRENAL Trial Investigators. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med. 2018;378(9):797-808.</ref>

Ostermayer at 16:25, 8 March 2026

2026-03-08T16:25:54Z

Show changes

Ostermayer at 00:42, 16 January 2026

2026-01-16T00:42:41Z

← Older revision		Revision as of 00:42, 16 January 2026
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	{{~~Adult top}} [[~~Sepsis (peds)~~]].''~~		{{AdultPage\|Sepsis (peds)}}
	==Background==		==Background==
	*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>		*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>

Tomfadial: Modify age group reference

2024-12-22T04:26:53Z

Modify age group reference

← Older revision		Revision as of 04:26, 22 December 2024
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	{{~~Peds~~ top}} [[Sepsis (peds)]].''		{{Adult top}} [[Sepsis (peds)]].''
	==Background==		==Background==
	*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>		*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>

Rossdonaldson1 at 14:52, 12 June 2024

2024-06-12T14:52:08Z

← Older revision		Revision as of 14:52, 12 June 2024
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			{{Peds top}} [[Sepsis (peds)]].''
	==Background==		==Background==
	*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>		*Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection<ref name="sepsis definition">Singer, Mervyn et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287</ref>