https://wikem.org/w/index.php?action=history&feed=atom&title=Riociguat 2026-04-19T13:56:35Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Riociguat&diff=225211&oldid=prev 2019-08-20T22:22:13Z

<p><span dir="auto"><span class="autocomment">Contraindications</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:22, 20 August 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l35">Line 35:</td> <td colspan="2" class="diff-lineno">Line 35:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Breastfeeding</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Breastfeeding</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Pulmonary veno-occlusive disease</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Pulmonary veno-occlusive disease</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*<del style="font-weight: bold; text-decoration: none;">[[</del>Idiopathic interstitial pneumonia<del style="font-weight: bold; text-decoration: none;">]]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Idiopathic interstitial pneumonia</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Adverse Reactions==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Adverse Reactions==</div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Riociguat&diff=171766&oldid=prev 2018-03-08T18:46:32Z

<p>Creation of Page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Vasodilator<br /> *Dosage Forms: Tab 0.5mg, 1mg, 1.5mg, 2mg, 2.5mg<br /> *Routes of Administration: Oral<br /> *Common Trade Names: Adempas<br /> <br /> ==Adult Dosing==<br /> ===Chronic thromboembolic pulmonary HTN===<br /> *0.5-2.5 mg PO TID<br /> ===Pulmonary arterial hypertension===<br /> *0.5-2.5 mg PO TID<br /> <br /> ==Pediatric Dosing==<br /> Safety/efficacy not established in pediatric patients<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: X<br /> *Lactation risk: Avoid Use<br /> ===Renal Dosing===<br /> *Adult:<br /> **CrCl &gt;15: No adjustment<br /> **CrCl &lt;15: Not defined<br /> *Pediatric: <br /> **Safety/efficacy not established in pediatric patients<br /> ===Hepatic Dosing===<br /> *Adult:<br /> **Child-Pugh Class A or B: No adjustment<br /> **Child-Pugh Class C: Not definied<br /> *Pediatric:<br /> **Safety/efficacy not established in pediatric patients<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Pregnancy<br /> *Breastfeeding<br /> *Pulmonary veno-occlusive disease<br /> *[[Idiopathic interstitial pneumonia]]<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Hemorrhage<br /> *[[Hemoptysis]], severe<br /> *[[Hypotension]], severe<br /> <br /> ===Common===<br /> *[[Headache]], [[dizziness]]<br /> *[[Gastritis]], dyspepsia, [[GERD]]<br /> *[[Nausea]], [[diarrhea]], [[vomiting]], [[constipation]]<br /> *[[Hypotension]]<br /> *[[Anemia]]<br /> <br /> ==Pharmacology==<br /> *Half-life: 12h<br /> *Metabolism: Liver extensively; CYP450: 1A1 (primary), 2C8, 2J2, 3A4/5 substrate<br /> *Excretion: Urine 40% (6% unchanged); Feces 53% (15% unchanged)<br /> <br /> ==Mechanism of Action==<br /> *Sensitizes and stimulates binding of soluble guanylate cyclase to nitric oxide in nitric oxide-sGC-cGMP pathway<br /> *Increases cGMP production and subsequent vasodilation<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren