Quetiapine - Revision history

Elcatracho: /* See Also */

2021-03-07T04:09:39Z

ClaireLewis: /* References */

2019-09-23T22:12:12Z

References

← Older revision		Revision as of 22:12, 23 September 2019
Line 56:		Line 56:
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Psychiatry]]

Neil.m.young: Text replacement - "α1" to "α₁"

2017-07-31T20:02:37Z

Text replacement - "α1" to "α<sub>1</sub>"

← Older revision		Revision as of 20:02, 31 July 2017
Line 46:		Line 46:
	==Mechanism of Action==		==Mechanism of Action==
	*Mechanism not well understood		*Mechanism not well understood
	*Antagonizes D2, 5HT, histamine H1, and α1 receptors, as well as muscarinic and norepinepherine receptors.		*Antagonizes D2, 5HT, histamine H1, and α<sub>1</sub> receptors, as well as muscarinic and norepinepherine receptors.
	==Comments==		==Comments==

Neil.m.young: Text replacement - "alpha" to "α"

2017-07-24T01:12:22Z

Text replacement - "alpha" to "α"

← Older revision		Revision as of 01:12, 24 July 2017
Line 46:		Line 46:
	==Mechanism of Action==		==Mechanism of Action==
	*Mechanism not well understood		*Mechanism not well understood
	*Antagonizes D2, 5HT, histamine H1, and ~~alpha1~~ receptors, as well as muscarinic and norepinepherine receptors.		*Antagonizes D2, 5HT, histamine H1, and α1 receptors, as well as muscarinic and norepinepherine receptors.
	==Comments==		==Comments==

Rossdonaldson1: Text replacement - "Pancreatitis" to "Pancreatitis"

2016-09-25T20:15:35Z

Text replacement - "*Pancreatitis" to "*Pancreatitis"

← Older revision		Revision as of 20:15, 25 September 2016
Line 29:		Line 29:
	*Agranulocytosis, neutropenia		*Agranulocytosis, neutropenia
	*Seizure		*Seizure
	*Pancreatitis		*[[Pancreatitis]]
	*Suicidal ideation		*Suicidal ideation
	===Common===		===Common===

ClaireLewis: Created page with "==Administration== Type: Atypical antipsychotics Dosage Forms: ER, IR Routes of Administration: oral Common Trade Names: Seroquel ==Adult Dosing== *25-400 mg PO 1-2 t..."

2016-09-25T17:13:41Z

Created page with "==Administration== *Type: Atypical antipsychotics *Dosage Forms: ER, IR *Routes of Administration: oral *Common Trade Names: Seroquel ==Adult Dosing== *25-400 mg PO 1-2 t..."

New page

==Administration==
*Type: Atypical [[antipsychotics]]
*Dosage Forms: ER, IR
*Routes of Administration: oral
*Common Trade Names: Seroquel

==Adult Dosing==
*25-400 mg PO 1-2 times daily
==Pediatric Dosing==
''Safety/efficacy not established in children <10 years old''
**25-400 mg PO 1-2 times daily

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal: No adjustment
*Hepatic dosing: initial dose 25 mg/day, titrate up slowly
*Concomitant use with strong CYP3A4 inducer: may need increased dose
*Concomitant use with strong CYP3A4 inhibitor: reduce quetiapine dose

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Prolonged QT interval, sudden cardiac death, syncope
*Neuroleptic malignant syndrome, tardive dyskinesia
*DKA
*Agranulocytosis, neutropenia
*Seizure
*Pancreatitis
*Suicidal ideation
===Common===
*Hypertension, weight gain, hyperlipidemia
*Abdominal pain, constipation, nausea/vomiting, xerostomia
*Somnolence, dizziness, asthenia, tremor, insomnia
*Extrapyramidal disease
*Headache
*URI-like symptoms

==Pharmacology==
*Half-life: 6-7 hours
*Metabolism: hepatic, extensive via CYP3A4
*Excretion: mostly renal

==Mechanism of Action==
*Mechanism not well understood
*Antagonizes D2, 5HT, histamine H1, and alpha1 receptors, as well as muscarinic and norepinepherine receptors.
==Comments==

==See Also==
*[[Antipsychotics]]
*[[Extrapyramidal reaction]]
*[[QT prolongation]]
==References==
<references/>
[[Category:Pharmacology]]

← Older revision		Revision as of 04:09, 7 March 2021
Line 51:		Line 51:
	==See Also==		==See Also==
	*[[Antipsychotics]]		*[[Antipsychotics]]
			*[[Antipsychotic toxicity]]
	*[[Extrapyramidal reaction]]		*[[Extrapyramidal reaction]]
	*[[QT prolongation]]		*[[QT prolongation]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:Psychiatry]]		[[Category:Psychiatry]]