Propafenone - Revision history

Blsimpso: /* Lactation risk */

2021-06-25T16:44:12Z

Lactation risk

← Older revision		Revision as of 16:44, 25 June 2021
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	===Lactation risk===		===Lactation risk===
	*		*Dosages up to 900mg/day not expected to cause adverse effects in breast fed infants

	===Renal Dosing===		===Renal Dosing===

2021-06-25T16:41:43Z

Pregnancy Rating

← Older revision		Revision as of 16:41, 25 June 2021
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	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*		*No assigned FDA category
			*No associated risk of miscarriage, birth defects, or adverse maternal or fetal outcomes with this drug

	===Lactation risk===		===Lactation risk===

2021-06-25T16:38:21Z

Hepatic Dosing

← Older revision		Revision as of 16:38, 25 June 2021
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	===Hepatic Dosing===		===Hepatic Dosing===
	*Adult:		*Adult: Administer 20-30% of normal IR dose and monitor closely; consider dose reduction if administering ER dose
	*Pediatric:		*Pediatric: No specified guidelines

	==Contraindications==		==Contraindications==

2021-06-25T16:33:03Z

Renal Dosing

← Older revision		Revision as of 16:33, 25 June 2021
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	===Renal Dosing===		===Renal Dosing===
	*Adult: No dosage adjustment needed		*Adult: No dosage adjustment needed
	*Pediatric: ~~N/A~~		*Pediatric: No dosage adjustment needed

	===Hepatic Dosing===		===Hepatic Dosing===

2021-06-25T16:31:11Z

Renal Dosing

← Older revision		Revision as of 16:31, 25 June 2021
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	===Renal Dosing===		===Renal Dosing===
	*Adult:		*Adult: No dosage adjustment needed
	*Pediatric:		*Pediatric: N/A

	===Hepatic Dosing===		===Hepatic Dosing===

2021-06-25T16:19:45Z

Adverse Reactions

← Older revision		Revision as of 16:19, 25 June 2021
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	*SLE		*SLE

	==Adverse Reactions==		==Adverse Reactions<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>==
	===Serious===		===Serious===
	* Cardiac arrhythmia (2%-10%; new or worsened)		* Cardiac arrhythmia (2%-10%; new or worsened)

2021-06-25T16:16:59Z

Serious

← Older revision		Revision as of 16:16, 25 June 2021
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			* Cardiac arrhythmia (2%-10%; new or worsened)
			* Cardiac failure (1%-4%)

	===Common===		===Common===

2021-06-25T16:13:44Z

Common

← Older revision		Revision as of 16:13, 25 June 2021
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	===Common===		===Common===
			* Unusual Taste (3%-23%)
			* Dizziness (4%-15%)
			* Nausea/Vomiting (<11%)

	==Pharmacology<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>==		==Pharmacology<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>==

2021-06-25T15:10:49Z

Pharmacologyhttps://www.drugs.com/ppa/propafenone.html

← Older revision		Revision as of 15:10, 25 June 2021
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	==Pharmacology<ref>https://www.drugs.com/ppa/propafenone.html</ref>==		==Pharmacology<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>==
	*Half-life: Extensive metabolizers: 2-10 hours; Poor metabolizers: 10-32 hours		*Half-life: Extensive metabolizers: 2-10 hours; Poor metabolizers: 10-32 hours
	*Metabolism: Hepatic via CYP2D6, CYP3A4 and CYP1A2		*Metabolism: Hepatic via CYP2D6, CYP3A4 and CYP1A2

2021-06-25T14:59:51Z

Mechanism of Action

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	*Excretion: Urine (<1% unchanged; remainder as glucuronide or sulfate conjugates); feces		*Excretion: Urine (<1% unchanged; remainder as glucuronide or sulfate conjugates); feces

	==Mechanism of Action==		==Mechanism of Action<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>==
	*Propafenone is a class 1c antiarrhythmic agent which possesses local anesthetic properties, blocks the fast inward sodium current, and slows the rate of increase of the action potential. Prolongs conduction and refractoriness in all areas of the myocardium, with a slightly more pronounced effect on intraventricular conduction; it prolongs effective refractory period, reduces spontaneous automaticity and exhibits some beta-blockade activity<ref>Drugs.com. 2021. Propafenone (Professional Patient Advice) - Drugs.com. [online] Available at: <https://www.drugs.com/ppa/propafenone.html> [Accessed 25 June 2021]</ref>		*Class 1c antiarrhythmic agent w/ local anesthetic properties
			*Blocks the fast inward sodium current, slowing the rate of increase of the action potential.
			*Prolongs conduction/refractoriness in myocardium, reduces spontaneous automaticity, and exhibits some beta-blockade activity

	==Comments==		==Comments==