Progressive multifocal leukoencephalopathy - Revision history

ClaireLewis at 22:31, 2 October 2019

2019-10-02T22:31:04Z

← Older revision		Revision as of 22:31, 2 October 2019
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	**[[AIDS]]		**[[AIDS]]
	**[[Leukemia]], [[lymphoma]], [[myeloproliferative disorders]] (with or without chemo)		**[[Leukemia]], [[lymphoma]], [[myeloproliferative disorders]] (with or without chemo)
	**Post solid organ or stem-cell transplant		**Post solid organ or [[stem cell transplant]]
	**Autoimmune disorders (with or without immune-modulating medications)		**Autoimmune disorders (with or without immune-modulating medications)
	**Medications: Natalizumab, rituximab, infliximab, [[mycophenolate mofetil]]		**Medications: Natalizumab, rituximab, infliximab, [[mycophenolate mofetil]]
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	*[[Altered mental status]]		*[[Altered mental status]]
	*Aphasia		*Aphasia
	*Ataxia		*[[Ataxia]]
	*Hemiparesis		*[[weakness\|Hemiparesis]]
	*Hemiplegia and visual field disturbances		*Hemiplegia and [[visual disturbances\|visual field disturbances]]
	*[[Seizure]]		*[[Seizure]]
	*[[Cranial nerve palsies]] (rare)		*[[Cranial nerve palsies]] (rare)
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	==Differential Diagnosis==		==Differential Diagnosis==
			{{AMS DDX}}

	==Evaluation==		==Evaluation==
	*Evaluate for other (especially easily treatable) causes of symptoms		*Evaluate for other (especially easily treatable) causes of symptoms
	*MRI brain: non-enhancing, multifocal areas of white matter demyelination		*[[brain MRI\|MRI brain]]: non-enhancing, multifocal areas of white matter demyelination
	*PCR for JC virus (CSF, blood, urine)		*PCR for JC virus (CSF, blood, urine)

ClaireLewis: Created page with "==Background== Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating CNS disorder Associated with reactivated JC virus *Seen almost exclusively in immuno..."

2016-11-13T04:57:28Z

Created page with "==Background== *Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating CNS disorder *Associated with reactivated JC virus *Seen almost exclusively in immuno..."

New page

==Background==
*Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating CNS disorder
*Associated with reactivated JC virus
*Seen almost exclusively in immunosuppressed patients, usually due to:
**[[AIDS]]
**[[Leukemia]], [[lymphoma]], [[myeloproliferative disorders]] (with or without chemo)
**Post solid organ or stem-cell transplant
**Autoimmune disorders (with or without immune-modulating medications)
**Medications: Natalizumab, rituximab, infliximab, [[mycophenolate mofetil]]

==Clinical Features==
*[[Altered mental status]]
*Aphasia
*Ataxia
*Hemiparesis
*Hemiplegia and visual field disturbances
*[[Seizure]]
*[[Cranial nerve palsies]] (rare)
*Cervical spine involvement (rare)

==Differential Diagnosis==

==Evaluation==
*Evaluate for other (especially easily treatable) causes of symptoms
*MRI brain: non-enhancing, multifocal areas of white matter demyelination
*PCR for JC virus (CSF, blood, urine)

==Management==
*Limit duration of immunosuppression
**HIV/AIDS patients, antiretroviral therapy is key
*Cidofovir may be useful in non-AIDS patients

==Disposition==

==See Also==

==External Links==

==References==
<references/>

[[Category:Neurology]]

Progressive multifocal leukoencephalopathy - Revision history

ClaireLewis at 22:31, 2 October 2019

ClaireLewis: Created page with "==Background== *Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating CNS disorder *Associated with reactivated JC virus *Seen almost exclusively in immuno..."

ClaireLewis: Created page with "==Background== Progressive multifocal leukoencephalopathy (PML) is a rare, demyelinating CNS disorder Associated with reactivated JC virus *Seen almost exclusively in immuno..."