https://wikem.org/w/index.php?action=history&feed=atom&title=Pramipexole 2026-04-18T15:03:57Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Pramipexole&diff=229672&oldid=prev 2019-09-23T21:51:21Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:51, 23 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l26">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Special Populations==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Special Populations==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===[[Drug pregnancy categories|Pregnancy Rating]]===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===[[Drug pregnancy categories|Pregnancy Rating]]===</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*Category C</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Caution advised during pregnancy</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Caution advised during pregnancy</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Risk of embryo-fetal death based on animal data at 4-5 MRHD</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Risk of embryo-fetal death based on animal data at 4-5 MRHD</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l85">Line 85:</td> <td colspan="2" class="diff-lineno">Line 86:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Neurology]]</ins></div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Pramipexole&diff=212793&oldid=prev 2019-04-25T05:22:39Z

<p><span dir="auto"><span class="autocomment">Rapid eye movement sleep behavior disorder</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:22, 25 April 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l17">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*0.125-0.5 mg PO qhs</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*0.125-0.5 mg PO qhs</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Rapid eye movement sleep behavior disorder===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Rapid eye movement sleep behavior disorder===</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>0.125-1.5 mg PO qhs</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*</ins>0.125-1.5 mg PO qhs</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pediatric Dosing==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pediatric Dosing==</div></td></tr> </table>

Jonwarren https://wikem.org/w/index.php?title=Pramipexole&diff=212791&oldid=prev 2019-04-25T05:21:51Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Dopamine agonist<br /> *Dosage Forms: TAB, ER TAB<br /> *Routes of Administration: Oral<br /> *Common Trade Names: Mirapex<br /> <br /> ==Adult Dosing==<br /> ===[[Parkinson's Disease]]===<br /> *Immediate release<br /> **0.5-1.5 mg PO TID<br /> ***Start 0.125 mg PO TID x7 days then 0.25 mg x7 days then increase 0.75 mg/day q7days to goal dose<br /> ***Max: 4.5 mg/day<br /> *Extended Release<br /> **0.375-4.5 mg ER PO daily<br /> ***Start 0.375 mg ER PO daily then titrate q7 days as above<br /> ===Restless legs syndrome===<br /> *0.125-0.5 mg PO qhs<br /> ===Rapid eye movement sleep behavior disorder===<br /> 0.125-1.5 mg PO qhs<br /> <br /> ==Pediatric Dosing==<br /> ===Restless leg syndrome===<br /> *5+ yo<br /> **0.125-0.375 mg PO qhs<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Caution advised during pregnancy<br /> *Risk of embryo-fetal death based on animal data at 4-5 MRHD<br /> <br /> ===Lactation risk===<br /> *Consider alternative<br /> *Theoretical decreased milk production based on decreased prolactin levels<br /> <br /> ===Renal Dosing===<br /> *Adult:<br /> **CrCl 30-50: Start 0.125 mg BID or 0.375 gm ER qod then titrate<br /> **CrCl &lt;30: Avoid use<br /> *Pediatric: Dose adjustment may be required, but has not been defined.<br /> <br /> ===Hepatic Dosing===<br /> *Adult: No adjustment<br /> *Pediatric: Not defined<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Avoid abrupt withdrawal<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Sudden sleep episodes<br /> *[[Hypotension]], orthostatic<br /> *[[Syncope]]<br /> *[[Dyskinesia]]<br /> *Extrapyramidal symptoms<br /> *[[Hallucination]]<br /> *[[Rhabdomyolysis]]<br /> *[[NMS]]-like symptoms if acute withdrawal<br /> <br /> ===Common===<br /> *[[Hypotension]]<br /> *[[Dyskinesia]], Extrapryamidal symptoms<br /> *[[Nausea]], [[constipation]], [[diarrhea]], [[vomiting]]<br /> *[[Insomnia]], [[hallucination]], [[headache]], [[fatigue]]<br /> *Confusion, abnormal dreams, amnesia, compulsive behaviors<br /> *Urinary frequency<br /> *Muscle spasm, peripheral edema<br /> <br /> ==Pharmacology==<br /> *Half-life: 8h (IR); 8.5h (ER)<br /> *Metabolism: None<br /> *Excretion: Urine 90%<br /> <br /> ==Mechanism of Action==<br /> *Stimulates dopamine receptors<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> *[[Parkinson's disease]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren