https://wikem.org/w/index.php?action=history&feed=atom&title=Pioglitazone 2026-04-18T16:13:16Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Pioglitazone&diff=247092&oldid=prev 2020-03-03T16:50:13Z

<p>Created page with &quot;==Administration== *Type: <a href="/wiki/Diabetes_medication" class="mw-redirect" title="Diabetes medication">Diabetes medication</a> *Dosage Forms: 15 mg, 30 mg, 45 mg *Routes of Administration: PO *Common Trade Names: Actos ==Adult Dosing== * 15-45 mg PO q...&quot;</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: [[Diabetes medication]]<br /> *Dosage Forms: 15 mg, 30 mg, 45 mg<br /> *Routes of Administration: PO<br /> *Common Trade Names: Actos<br /> <br /> ==Adult Dosing==<br /> * 15-45 mg PO qd<br /> * Max: 45 mg/day<br /> <br /> ==Pediatric Dosing==<br /> * &gt;15-30 mg PO qd<br /> * Start with 15 mg PO qd<br /> * Max: 45 mg/day<br /> * Give with metformin<br /> <br /> ==Special Populations==<br /> <br /> * [[Pregnancy Rating]]: C<br /> * [[Lactation risk]]: No recommended<br /> <br /> * Renal Dosing: no adjustment<br /> * Hepatic Dosing: no adjustment<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Pediatric patients &lt;15 yo<br /> *Type 1 diabetes<br /> * DKA<br /> * Active bladder cancer<br /> * [[CHF]] (symptomatic; NYHA Class III-IV)<br /> <br /> ==== Caution ====<br /> * [[CHF]] (NYHA Class I-II)<br /> * [[CHF]] Risk<br /> * Edema<br /> * Hepatic impairment<br /> * Bladder cancer history<br /> * Premenopausal anovulatory patients<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> * [[CHF]]<br /> * Hepatotoxicity<br /> * Diabetic macular edema<br /> * Bladder cancer risk<br /> * Fractures (females)<br /> <br /> ===Common===<br /> * [[URI]]<br /> * [[Headache]]<br /> * Myalgia<br /> * Weight gain<br /> * Edema<br /> * Fluid retention<br /> * Flatulence<br /> * [[Anemia]]<br /> * Ovulation induction<br /> <br /> ==Pharmacology==<br /> *Half-life: 3-7 hrs; 16-24 hrs (metabolites)<br /> *Metabolism: Liver (CYP450)<br /> *Excretion: Urine; bile<br /> <br /> ==Mechanism of Action==<br /> * Increases insulin sensitivity<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> * [[Diabetes medication]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> * Pioglitazone [monograph]. Epocrates Version. 20.2 [iPhone]. Epocrates, Inc, San Francisco, CA. Available from https://online.epocrates.com/. Accessed March 3, 2020.<br /> * Actos. Food and Drug Administration Web site.* https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21073lbl.pdf. Accessed March 3, 2020.<br /> <br /> [[Category:Pharmacology]]</div>

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