Nafcillin - Revision history

Danbot: Remove disease-specific entries now covered by AntibioticDose (3 sections)

2026-03-20T11:08:22Z

Remove disease-specific entries now covered by AntibioticDose (3 sections)

← Older revision		Revision as of 11:08, 20 March 2026
Line 8:		Line 8:
	*0.5-2 g IV q4-6h		*0.5-2 g IV q4-6h
	*Max: 12 g/day IV; Info: dose, duration varies with infection type, severity		*Max: 12 g/day IV; Info: dose, duration varies with infection type, severity
	~~===Bacterial [[Meningitis]]===~~
	*100-200mg/kg/day IV divided q4-6h
	*Max: 12 g/day
	===Renal Dosing===		===Renal Dosing===
	*Consider decrease dose if concomitant hepatic impairment		*Consider decrease dose if concomitant hepatic impairment
Line 43:		Line 40:
	*1 mo-16 yo		*1 mo-16 yo
	*Dose: 50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day		*Dose: 50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day
	~~===[[Endocarditis]], Native valve===~~
	*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x3-5 days
	~~===[[Endocarditis]], Prosthetic valve===~~
	*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*No adjustment unless concomitant hepatic impairment		*No adjustment unless concomitant hepatic impairment

Danbot: Remove disease-specific dosing covered by dynamic SMW tables

2026-03-20T02:58:01Z

Remove disease-specific dosing covered by dynamic SMW tables

← Older revision		Revision as of 02:58, 20 March 2026
Line 8:		Line 8:
	*0.5-2 g IV q4-6h		*0.5-2 g IV q4-6h
	*Max: 12 g/day IV; Info: dose, duration varies with infection type, severity		*Max: 12 g/day IV; Info: dose, duration varies with infection type, severity
	~~===[[Osteomyelitis]]===~~
	*1-2 g IV q4h x4-6wk
	*Max: 12 g/day
	===Bacterial [[Meningitis]]===		===Bacterial [[Meningitis]]===
	*100-200mg/kg/day IV divided q4-6h		*100-200mg/kg/day IV divided q4-6h
	*Max: 12 g/day		*Max: 12 g/day
	~~===[[Endocarditis]], Native valve===~~
	*2 g IV q4h x4-6wk
	*Max: 12 g/day; Info: give with [[gentamicin]] 1mg/kg IV q8h x3-5 days
	~~===[[Endocarditis]], Prosthetic valve===~~
	*2 g IV q4h x6wk
	*Max: 12 g/day; Info: give with [[gentamicin]] 1-2mg/kg IV q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*Consider decrease dose if concomitant hepatic impairment		*Consider decrease dose if concomitant hepatic impairment

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:39Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:37, 20 March 2026
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
			===Bacterial infections===
			*0.5-2 g IV q4-6h
			*Max: 12 g/day IV; Info: dose, duration varies with infection type, severity
			===[[Osteomyelitis]]===
			*1-2 g IV q4h x4-6wk
			*Max: 12 g/day
			===Bacterial [[Meningitis]]===
			*100-200mg/kg/day IV divided q4-6h
			*Max: 12 g/day
			===[[Endocarditis]], Native valve===
			*2 g IV q4h x4-6wk
			*Max: 12 g/day; Info: give with [[gentamicin]] 1mg/kg IV q8h x3-5 days
			===[[Endocarditis]], Prosthetic valve===
			*2 g IV q4h x6wk
			*Max: 12 g/day; Info: give with [[gentamicin]] 1-2mg/kg IV q8h x2wk and rifampin
			===Renal Dosing===
			*Consider decrease dose if concomitant hepatic impairment
			===Hepatic Dosing===
			*Consider decrease dose if concomitant renal impairment


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			===Bacterial Infections===
			*0-4 wk old, <1200 g
			*Dose: 50mg/kg/day IV divided q12h
			*<1 wk old, 1200-2000 g
			*Dose: 50mg/kg/day IV divided q12h
			*<1 wk old, >2000 g
			*Dose: 75mg/kg/day IV divided q8h
			*1 wk old-1 mo, 1200-2000 g
			*Dose: 75mg/kg/day IV divided q8h
			*1 wk old-1 mo, >2000 g
			*Dose: 100mg/kg/day IV divided q6h
			*1 mo-16 yo
			*Dose: 50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day
			===[[Endocarditis]], Native valve===
			*[1 mo-16 yo]
			*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x3-5 days
			===[[Endocarditis]], Prosthetic valve===
			*[1 mo-16 yo]
			*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x2wk and rifampin
			===Renal Dosing===
			*No adjustment unless concomitant hepatic impairment
			*CrCl 10-29: 9-25mg/kg q6h if concomitant hepatic impairment; CrCl <10: 7.5-15mg/kg q6h if concomitant hepatic impairment
			===Hepatic Dosing===
			*Consider decrease dose if concomitant renal impairment

			==Safety==
			*Pregnancy: Class B
			*Lactation: Probably Safe


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:52:42Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:52, 20 March 2026
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
	===~~Bacterial infections~~===		===Indications by Disease===
	*0.5-2 g IV q4-6h		{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Adult]]
	*Max: ~~12 g/day IV; Info: dose, duration varies with infection type, severity~~		\|?Treats disease=Disease
	~~===~~[[~~Osteomyelitis]]===~~		\|?Has Dose=Dose
	*1-2 g IV q4h x4-6wk		\|?Has Context=Context
	*Max: ~~12 g/day~~		\|format=table
	~~===Bacterial [[Meningitis~~]]~~===~~		\|limit=50
	*100-200mg/kg/day IV divided q4-6h		\|mainlabel=-
	*Max: 12 g/day		\|headers=show
	~~===~~[[~~Endocarditis]], Native valve===~~		\|sort=Treats disease
	*2 g IV q4h x4-6wk		}}
	*Max: ~~12 g/day; Info~~: ~~give with [[gentamicin~~]] ~~1mg/kg IV q8h x3-5 days~~
	===~~[[Endocarditis]], Prosthetic valve~~===
	*2 g IV q4h x6wk
	*Max: 12 g/day; Info: give with [[gentamicin]] 1-~~2mg/kg IV q8h x2wk and rifampin~~
	=~~==Renal Dosing===~~
	*Consider decrease dose if concomitant hepatic impairment
	~~===Hepatic Dosing==~~=
	*Consider decrease dose if concomitant renal impairment

	==Pediatric Dosing==		==Pediatric Dosing==
	===~~Bacterial Infections~~===		===Indications by Disease===
	*0-4 wk old, <1200 g		{{#ask: [[Has DrugName::Nafcillin]] [[Has Population::Pediatric]]
	*Dose: 50mg/kg/day IV divided q12h		\|?Treats disease=Disease
	*<1 wk old, 1200-2000 g		\|?Has Dose=Dose
	*Dose: 50mg/kg/day IV divided q12h		\|?Has Context=Context
	*<1 wk old, >2000 g		\|format=table
	*Dose: 75mg/kg/day IV divided q8h		\|limit=50
	*1 wk old-1 mo, 1200-2000 g		\|mainlabel=-
	*Dose: 75mg/kg/day IV divided q8h		\|headers=show
	*1 wk old-1 mo, >2000 g		\|sort=Treats disease
	*Dose: 100mg/kg/day IV divided q6h		}}
	*1 mo-16 yo
	*Dose: ~~50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day~~
	~~===~~[[~~Endocarditis]], Native valve===~~
	*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: ~~12 g/day; Info~~: ~~give with [[gentamicin~~]] ~~3mg/kg/day IV divided q8h x3-5 days~~
	~~===~~[[~~Endocarditis]], Prosthetic valve===~~
	*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: ~~12 g/day; Info~~: ~~give with [[gentamicin~~]] ~~3mg/kg/day IV divided q8h x2wk and rifampin~~
	===~~Renal Dosing~~===
	*No adjustment unless concomitant hepatic impairment
	*CrCl 10-29: 9-25mg/kg q6h if concomitant hepatic impairment; CrCl <10: 7.5-~~15mg/kg q6h if concomitant hepatic impairment~~
	=~~==Hepatic Dosing===~~
	*Consider decrease dose if concomitant renal impairment

	=~~=Safety==~~
	*Pregnancy: Class B
	*Lactation: Probably Safe

	==Contraindications==		==Contraindications==

Ostermayer at 17:41, 18 July 2025

2025-07-18T17:41:36Z

← Older revision		Revision as of 17:41, 18 July 2025
Line 1:		Line 1:
	==General==		==General==
	*Type: [[Is DrugClass::Penicillin]], Beta-Lactamase-Resistant Penicillin		*Type: [[Is DrugClass::Penicillin]], [[Is PenicillinType::Beta-Lactamase-Resistant Penicillin]]
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Nafcil, Nallpen		*Common Trade Names: Nafcil, Nallpen

Ostermayer at 17:15, 18 July 2025

2025-07-18T17:15:39Z

← Older revision		Revision as of 17:15, 18 July 2025
Line 1:		Line 1:
	==General==		==General==
	*Type: [[Penicillin]], Beta-Lactamase-Resistant Penicillin		*Type: [[Is DrugClass::Penicillin]], Beta-Lactamase-Resistant Penicillin
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Nafcil, Nallpen		*Common Trade Names: Nafcil, Nallpen

ClaireLewis: /* References */

2019-09-22T23:46:18Z

References

← Older revision		Revision as of 23:46, 22 September 2019
Line 220:		Line 220:
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Rossdonaldson1: Text replacement - " gentamicin " to " gentamicin "

2016-09-08T10:28:18Z

Text replacement - " gentamicin " to " gentamicin "

← Older revision		Revision as of 10:28, 8 September 2016
Line 16:		Line 16:
	===[[Endocarditis]], Native valve===		===[[Endocarditis]], Native valve===
	*2 g IV q4h x4-6wk		*2 g IV q4h x4-6wk
	*Max: 12 g/day; Info: give with gentamicin 1mg/kg IV q8h x3-5 days		*Max: 12 g/day; Info: give with [[gentamicin]] 1mg/kg IV q8h x3-5 days
	===[[Endocarditis]], Prosthetic valve===		===[[Endocarditis]], Prosthetic valve===
	*2 g IV q4h x6wk		*2 g IV q4h x6wk
	*Max: 12 g/day; Info: give with gentamicin 1-2mg/kg IV q8h x2wk and rifampin		*Max: 12 g/day; Info: give with [[gentamicin]] 1-2mg/kg IV q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*Consider decrease dose if concomitant hepatic impairment		*Consider decrease dose if concomitant hepatic impairment
Line 41:		Line 41:
	===[[Endocarditis]], Native valve===		===[[Endocarditis]], Native valve===
	*[1 mo-16 yo]		*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x3-5 days		*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x3-5 days
	===[[Endocarditis]], Prosthetic valve===		===[[Endocarditis]], Prosthetic valve===
	*[1 mo-16 yo]		*[1 mo-16 yo]
	*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x2wk and rifampin		*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with [[gentamicin]] 3mg/kg/day IV divided q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*No adjustment unless concomitant hepatic impairment		*No adjustment unless concomitant hepatic impairment

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-22T13:07:38Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 13:07, 22 July 2016
Line 12:		Line 12:
	*Max: 12 g/day		*Max: 12 g/day
	===Bacterial [[Meningitis]]===		===Bacterial [[Meningitis]]===
	*100-~~200 mg~~/kg/day IV divided q4-6h		*100-200mg/kg/day IV divided q4-6h
	*Max: 12 g/day		*Max: 12 g/day
	===[[Endocarditis]], Native valve===		===[[Endocarditis]], Native valve===
Line 28:		Line 28:
	===Bacterial Infections===		===Bacterial Infections===
	*0-4 wk old, <1200 g		*0-4 wk old, <1200 g
	*Dose: ~~50 mg~~/kg/day IV divided q12h		*Dose: 50mg/kg/day IV divided q12h
	*<1 wk old, 1200-2000 g		*<1 wk old, 1200-2000 g
	*Dose: ~~50 mg~~/kg/day IV divided q12h		*Dose: 50mg/kg/day IV divided q12h
	*<1 wk old, >2000 g		*<1 wk old, >2000 g
	*Dose: 75mg/kg/day IV divided q8h		*Dose: 75mg/kg/day IV divided q8h
Line 36:		Line 36:
	*Dose: 75mg/kg/day IV divided q8h		*Dose: 75mg/kg/day IV divided q8h
	*1 wk old-1 mo, >2000 g		*1 wk old-1 mo, >2000 g
	*Dose: ~~100 mg~~/kg/day IV divided q6h		*Dose: 100mg/kg/day IV divided q6h
	*1 mo-16 yo		*1 mo-16 yo
	*Dose: 50-~~100 mg~~/kg/day IV divided q6h if mild-mod. infection; 100-~~200 mg~~/kg/day IV divided q4-6h if severe infection; Max: 12 g/day		*Dose: 50-100mg/kg/day IV divided q6h if mild-mod. infection; 100-200mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day
	===[[Endocarditis]], Native valve===		===[[Endocarditis]], Native valve===
	*[1 mo-16 yo]		*[1 mo-16 yo]
	*Dose: ~~200 mg~~/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x3-5 days		*Dose: 200mg/kg/day IV divided q4-6h x6wk; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x3-5 days
	===[[Endocarditis]], Prosthetic valve===		===[[Endocarditis]], Prosthetic valve===
	*[1 mo-16 yo]		*[1 mo-16 yo]
	*Dose: ~~200 mg~~/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x2wk and rifampin		*Dose: 200mg/kg/day IV divided q4-6h x6wk or longer; Max: 12 g/day; Info: give with gentamicin 3mg/kg/day IV divided q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*No adjustment unless concomitant hepatic impairment		*No adjustment unless concomitant hepatic impairment

Neil.m.young: Text replacement - "2 mg" to "2mg"

2016-07-22T12:34:07Z

Text replacement - "2 mg" to "2mg"

← Older revision		Revision as of 12:34, 22 July 2016
Line 19:		Line 19:
	===[[Endocarditis]], Prosthetic valve===		===[[Endocarditis]], Prosthetic valve===
	*2 g IV q4h x6wk		*2 g IV q4h x6wk
	*Max: 12 g/day; Info: give with gentamicin 1-~~2 mg~~/kg IV q8h x2wk and rifampin		*Max: 12 g/day; Info: give with gentamicin 1-2mg/kg IV q8h x2wk and rifampin
	===Renal Dosing===		===Renal Dosing===
	*Consider decrease dose if concomitant hepatic impairment		*Consider decrease dose if concomitant hepatic impairment