Mucositis - Revision history

Rossdonaldson1: /* Clinical features */

2022-01-06T06:11:48Z

Clinical features

← Older revision		Revision as of 06:11, 6 January 2022
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	==Clinical features==		==Clinical features==
	[[File:PMC3948915 pone.0091733.g001.png\|thumb\|Oral mucositis is a side-effect of radiation treatment.]]		[[File:PMC3948915 pone.0091733.g001.png\|thumb\|Oral mucositis is a side-effect of radiation treatment.]]
			[[File:PMC2902123 IJPC-15-95-g001.png\|thumb\|Oral mucositis in a patient who have undergone radiotherapy.]]
	*Stomatotoxic effect begins approximately 7 days after therapy		*Stomatotoxic effect begins approximately 7 days after therapy
	*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations		*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations

Rossdonaldson1: /* Clinical features */

2022-01-06T06:10:27Z

Clinical features

← Older revision		Revision as of 06:10, 6 January 2022
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	==Clinical features==		==Clinical features==
			[[File:PMC3948915 pone.0091733.g001.png\|thumb\|Oral mucositis is a side-effect of radiation treatment.]]
	*Stomatotoxic effect begins approximately 7 days after therapy		*Stomatotoxic effect begins approximately 7 days after therapy
	*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations		*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations

Rossdonaldson1 at 05:24, 27 November 2021

2021-11-27T05:24:29Z

← Older revision		Revision as of 05:24, 27 November 2021
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	==Background==		==Background==
	<ref>Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019;55(2):25. Published 2019 Jan 22. doi:10.3390/medicina55020025</ref>		*One of the most common side effects of cancer treatment with chemotherapy or radiation<ref>Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019;55(2):25. Published 2019 Jan 22. doi:10.3390/medicina55020025</ref>
	*One of the most common side effects of cancer treatment with chemotherapy or radiation
	*Occurs in almost all cases of head or neck radiation		*Occurs in almost all cases of head or neck radiation
	*20-80% of people who receive chemotherapy		*20-80% of people who receive chemotherapy
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	<references/>		<references/>
	*Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology (Williston Park). 2003;17(12):1767-1792.		*Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology (Williston Park). 2003;17(12):1767-1792.

			[[Category:ENT]]

ClaireLewis at 16:10, 8 February 2021

2021-02-08T16:10:24Z

← Older revision		Revision as of 16:10, 8 February 2021
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	==Clinical features==		==Clinical features==
			*Stomatotoxic effect begins approximately 7 days after therapy
			*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations
	*Erythema and ulcerations of the mucosal lining of the gastrointestinal tract		*Erythema and ulcerations of the mucosal lining of the gastrointestinal tract
	*Causes dysphagia, changes in taste, secondary infections, weight loss		*Causes [[dysphagia]], changes in taste, secondary infections, weight loss
	**Oral mucositis is associated with increased inpatient hospitalization duration, bacteremia and higher 100‐day mortality.		**Oral mucositis is associated with increased inpatient hospitalization duration, [[bacteremia]] and higher 100‐day mortality.
	**GI mucositis is associated with nausea, vomiting, bloating, diarrhea, intestinal cramping and anal pain.		**GI mucositis is associated with [[nausea/vomiting]], bloating, [[diarrhea]], intestinal cramping and anal pain.

	==Differential Diagnosis==		==Differential Diagnosis==
	*Oral candidiasis		*[[Oral candidiasis]]
	*Herpes simplex virus infection		*[[Herpes simplex virus]] infection
	*Acute ~~Graft~~-versus-~~Host~~ disease		*Acute [[graft-versus-host disease]]

	==Evaluation==		==Evaluation==
	Grading system: National Cancer Institute Common Terminology Criteria for Adverse Events(CTCAE)<ref>Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed January 6th, 2020)</ref>		*Diagnosis is typically clinical, based on history and exam
			*Grading system: National Cancer Institute Common Terminology Criteria for Adverse Events(CTCAE)<ref>Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed January 6th, 2020)</ref>
	*Grade 1 - Aysymptomatic or mild symptoms, no intervention needed		*Grade 1 - Aysymptomatic or mild symptoms, no intervention needed
	*Grade 2 - Moderate pain or ulcer that does not interfere with oral intake, modified diet indicated		*Grade 2 - Moderate pain or ulcer that does not interfere with oral intake, modified diet indicated
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	*Grade 5 - Death		*Grade 5 - Death
	===Workup===		===Workup===
	~~No specific requirements, base on patients~~ clinical ~~presentation~~		*Typically clinical diagnosis

	~~===Diagnosis===~~
	~~Clinical history and exam~~
	*Stomatotoxic effect begins approximately 7 days after therapy
	*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations

	==Management==		==Management==
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	==Disposition==		==Disposition==
	*~~Will require admission if~~ PO intolerance, significant weight loss		*Admit for PO intolerance, significant weight loss, otherwise typically discharge

	==See Also==		==See Also==

Ryantenold: /* Disposition */

2021-01-07T05:43:46Z

Disposition

← Older revision		Revision as of 05:43, 7 January 2021
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	==Disposition==		==Disposition==
			*Will require admission if PO intolerance, significant weight loss

	==See Also==		==See Also==

Ryantenold: /* Workup */

2021-01-07T05:41:52Z

Workup

← Older revision		Revision as of 05:41, 7 January 2021
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	*Grade 5 - Death		*Grade 5 - Death
	===Workup===		===Workup===
	No specific requirements		No specific requirements, base on patients clinical presentation
	~~Taylor to~~ patients presentation

	===Diagnosis===		===Diagnosis===

Ryantenold: /* Workup */

2021-01-07T05:41:00Z

Workup

← Older revision		Revision as of 05:41, 7 January 2021
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	*Grade 5 - Death		*Grade 5 - Death
	===Workup===		===Workup===
			No specific requirements
			Taylor to patients presentation

	===Diagnosis===		===Diagnosis===

Ryantenold: /* Diagnosis */

2021-01-07T05:38:42Z

Diagnosis

← Older revision		Revision as of 05:38, 7 January 2021
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	Clinical history and exam		Clinical history and exam
	*Stomatotoxic effect begins approximately 7 days after therapy		*Stomatotoxic effect begins approximately 7 days after therapy
	*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth-->elevated, white desquamative patches-->epithelial sloughing leading to shallow ulcerations with pseudomembranous look-->coalesce into large, painful ulcerations		*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations

	==Management==		==Management==

Ryantenold: /* Diagnosis */

2021-01-07T05:37:40Z

Diagnosis

← Older revision		Revision as of 05:37, 7 January 2021
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	===Diagnosis===		===Diagnosis===
	Clinical history and exam		Clinical history and exam
			*Stomatotoxic effect begins approximately 7 days after therapy
			*Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth-->elevated, white desquamative patches-->epithelial sloughing leading to shallow ulcerations with pseudomembranous look-->coalesce into large, painful ulcerations

	==Management==		==Management==

Ryantenold: /* Diagnosis */

2021-01-07T05:30:02Z

Diagnosis

← Older revision		Revision as of 05:30, 7 January 2021
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	===Diagnosis===		===Diagnosis===
			Clinical history and exam

	==Management==		==Management==