Loop diuretic - Revision history

Danbot: Strip excess bold

2026-03-22T09:12:34Z

Strip excess bold

← Older revision		Revision as of 09:12, 22 March 2026
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	== Background ==		== Background ==
	* Mechanism: Inhibits Na-K-2Cl carrier in the ~~'''~~thick ascending Loop of Henle~~'''~~^1^		* Mechanism: Inhibits Na-K-2Cl carrier in the thick ascending Loop of Henle^1^
	* Potency: Highest among diuretic classes		* Potency: Highest among diuretic classes
	* ~~'''~~Adverse Effects~~'''~~		* Adverse Effects
	** [[Hypokalemia]] (most common)		** [[Hypokalemia]] (most common)
	** [[Hypomagnesemia]], [[hyponatremia]], [[hypocalcemia]]		** [[Hypomagnesemia]], [[hyponatremia]], [[hypocalcemia]]
	** Ototoxicity (associated with rapid IV push)		** Ototoxicity (associated with rapid IV push)
	** Pre-renal [[Acute Kidney Injury\|AKI]] (due to over-diuresis)		** Pre-renal [[Acute Kidney Injury\|AKI]] (due to over-diuresis)
	* ~~'''~~Sulfa Allergy:~~'''~~ Most are sulfonamide derivatives; cross-reactivity is rare but possible		* Sulfa Allergy: Most are sulfonamide derivatives; cross-reactivity is rare but possible

	== Key Agents ==		== Key Agents ==
	* ~~'''~~[[Has DrugName::Furosemide]]~~'''~~ (Lasix)		* [[Has DrugName::Furosemide]] (Lasix)
	** ~~'''~~Bioavailability:~~'''~~ Highly variable PO absorption (10-90%, avg ~50%)		** Bioavailability: Highly variable PO absorption (10-90%, avg ~50%)
	*** IV dose is approx 2x as potent as PO dose (e.g., 20mg IV ≈ 40mg PO)		*** IV dose is approx 2x as potent as PO dose (e.g., 20mg IV ≈ 40mg PO)
	** ~~'''~~Dosing:~~'''~~ In [[CHF]], usually start with 1-2.5x the patient's daily home dose IV		** Dosing: In [[CHF]], usually start with 1-2.5x the patient's daily home dose IV

	* ~~'''~~[[Has DrugName::Bumetanide]]~~'''~~ (Bumex)		* [[Has DrugName::Bumetanide]] (Bumex)
	** ~~'''~~Potency:~~'''~~ ~40x more potent than furosemide		** Potency: ~40x more potent than furosemide
	*** 1 mg Bumetanide ≈ 40 mg Furosemide		*** 1 mg Bumetanide ≈ 40 mg Furosemide
	** ~~'''~~Bioavailability:~~'''~~ High and reliable absorption (>80%)		** Bioavailability: High and reliable absorption (>80%)
	** Often reserved for patients refractory to furosemide or with severe gut edema		** Often reserved for patients refractory to furosemide or with severe gut edema

	* ~~'''~~[[Has DrugName::Torsemide]]~~'''~~ (Demadex)		* [[Has DrugName::Torsemide]] (Demadex)
	** ~~'''~~Kinetics:~~'''~~ Longer half-life than furosemide		** Kinetics: Longer half-life than furosemide
	** ~~'''~~Bioavailability:~~'''~~ Excellent oral absorption		** Bioavailability: Excellent oral absorption
	*** PO dose is essentially equivalent to IV dose		*** PO dose is essentially equivalent to IV dose
	** Less common in acute resuscitation; helpful for chronic management		** Less common in acute resuscitation; helpful for chronic management

	* ~~'''~~[[Has DrugName::Ethacrynic acid]]~~'''~~ (Edecrin)		* [[Has DrugName::Ethacrynic acid]] (Edecrin)
	** ~~'''~~Class:~~'''~~ Phenoxyacetic acid derivative (not a sulfonamide)		** Class: Phenoxyacetic acid derivative (not a sulfonamide)
	** ~~'''~~Indication:~~'''~~ The only alternative for patients with ''severe'' or anaphylactic ~~'''~~sulfa allergy~~'''~~		** Indication: The only alternative for patients with ''severe'' or anaphylactic sulfa allergy
	** ~~'''~~Toxicity:~~'''~~ Highest risk of ototoxicity among loop diuretics		** Toxicity: Highest risk of ototoxicity among loop diuretics
	** Seldom used as first-line due to side effect profile		** Seldom used as first-line due to side effect profile

Ostermayer: /* Background */

2026-01-28T00:56:21Z

Background

← Older revision		Revision as of 00:56, 28 January 2026
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	* Potency: Highest among diuretic classes		* Potency: Highest among diuretic classes
	* '''Adverse Effects'''		* '''Adverse Effects'''
	** Hypokalemia (most common)		** [[Hypokalemia]] (most common)
	** Hypomagnesemia, hyponatremia, hypocalcemia		** [[Hypomagnesemia]], [[hyponatremia]], [[hypocalcemia]]
	** Ototoxicity (associated with rapid IV push)		** Ototoxicity (associated with rapid IV push)
	** Pre-renal [[Acute Kidney Injury\|AKI]] (due to over-diuresis)		** Pre-renal [[Acute Kidney Injury\|AKI]] (due to over-diuresis)

Ostermayer at 00:45, 28 January 2026

2026-01-28T00:45:18Z

← Older revision		Revision as of 00:45, 28 January 2026
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	== Key Agents ==		== Key Agents ==
	* '''[[Furosemide]]''' (Lasix)		* '''[[Has DrugName::Furosemide]]''' (Lasix)
	** '''Bioavailability:''' Highly variable PO absorption (10-90%, avg ~50%)		** '''Bioavailability:''' Highly variable PO absorption (10-90%, avg ~50%)
	*** IV dose is approx 2x as potent as PO dose (e.g., 20mg IV ≈ 40mg PO)		*** IV dose is approx 2x as potent as PO dose (e.g., 20mg IV ≈ 40mg PO)
	** '''Dosing:''' In [[CHF]], usually start with 1-2.5x the patient's daily home dose IV		** '''Dosing:''' In [[CHF]], usually start with 1-2.5x the patient's daily home dose IV

	* '''[[Has ~~Diuretic~~::Bumetanide]]''' (Bumex)		* '''[[Has DrugName::Bumetanide]]''' (Bumex)
	** '''Potency:''' ~40x more potent than furosemide		** '''Potency:''' ~40x more potent than furosemide
	*** 1 mg Bumetanide ≈ 40 mg Furosemide		*** 1 mg Bumetanide ≈ 40 mg Furosemide
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	** Often reserved for patients refractory to furosemide or with severe gut edema		** Often reserved for patients refractory to furosemide or with severe gut edema

	* '''[[Has ~~Diuretic~~::Torsemide]]''' (Demadex)		* '''[[Has DrugName::Torsemide]]''' (Demadex)
	** '''Kinetics:''' Longer half-life than furosemide		** '''Kinetics:''' Longer half-life than furosemide
	** '''Bioavailability:''' Excellent oral absorption		** '''Bioavailability:''' Excellent oral absorption
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	** Less common in acute resuscitation; helpful for chronic management		** Less common in acute resuscitation; helpful for chronic management

	* '''[[Has ~~Diuretic~~::Ethacrynic acid]]''' (Edecrin)		* '''[[Has DrugName::Ethacrynic acid]]''' (Edecrin)
	** '''Class:''' Phenoxyacetic acid derivative (not a sulfonamide)		** '''Class:''' Phenoxyacetic acid derivative (not a sulfonamide)
	** '''Indication:''' The only alternative for patients with ''severe'' or anaphylactic '''sulfa allergy'''		** '''Indication:''' The only alternative for patients with ''severe'' or anaphylactic '''sulfa allergy'''

Ostermayer: /* See Also */

2026-01-28T00:36:39Z

Ostermayer: Created page with "== Background == * Mechanism: Inhibits Na-K-2Cl carrier in the '''thick ascending Loop of Henle'''^1^ * Potency: Highest among diuretic classes * '''Adverse Effects''' Hypokalemia (most common) Hypomagnesemia, hyponatremia, hypocalcemia Ototoxicity (associated with rapid IV push) Pre-renal AKI (due to over-diuresis) * '''Sulfa Allergy:''' Most are sulfonamide derivatives; cross-reactivity is rare but possible == Key Agents == * '''F..."

2026-01-28T00:36:24Z

Created page with "== Background == * Mechanism: Inhibits Na-K-2Cl carrier in the '''thick ascending Loop of Henle'''^1^ * Potency: Highest among diuretic classes * '''Adverse Effects''' ** Hypokalemia (most common) ** Hypomagnesemia, hyponatremia, hypocalcemia ** Ototoxicity (associated with rapid IV push) ** Pre-renal AKI (due to over-diuresis) * '''Sulfa Allergy:''' Most are sulfonamide derivatives; cross-reactivity is rare but possible == Key Agents == * '''F..."

New page

== Background ==
* Mechanism: Inhibits Na-K-2Cl carrier in the '''thick ascending Loop of Henle'''^1^
* Potency: Highest among diuretic classes
* '''Adverse Effects'''
** Hypokalemia (most common)
** Hypomagnesemia, hyponatremia, hypocalcemia
** Ototoxicity (associated with rapid IV push)
** Pre-renal [[Acute Kidney Injury|AKI]] (due to over-diuresis)
* '''Sulfa Allergy:''' Most are sulfonamide derivatives; cross-reactivity is rare but possible

== Key Agents ==
* '''[[Furosemide]]''' (Lasix)
** '''Bioavailability:''' Highly variable PO absorption (10-90%, avg ~50%)
*** IV dose is approx 2x as potent as PO dose (e.g., 20mg IV ≈ 40mg PO)
** '''Dosing:''' In [[CHF]], usually start with 1-2.5x the patient's daily home dose IV

* '''[[Has Diuretic::Bumetanide]]''' (Bumex)
** '''Potency:''' ~40x more potent than furosemide
*** 1 mg Bumetanide ≈ 40 mg Furosemide
** '''Bioavailability:''' High and reliable absorption (>80%)
** Often reserved for patients refractory to furosemide or with severe gut edema

* '''[[Has Diuretic::Torsemide]]''' (Demadex)
** '''Kinetics:''' Longer half-life than furosemide
** '''Bioavailability:''' Excellent oral absorption
*** PO dose is essentially equivalent to IV dose
** Less common in acute resuscitation; helpful for chronic management

* '''[[Has Diuretic::Ethacrynic acid]]''' (Edecrin)
** '''Class:''' Phenoxyacetic acid derivative (not a sulfonamide)
** '''Indication:''' The only alternative for patients with ''severe'' or anaphylactic '''sulfa allergy'''
** '''Toxicity:''' Highest risk of ototoxicity among loop diuretics
** Seldom used as first-line due to side effect profile

== See Also ==
* [[Heart Failure]]
* [[Pulmonary Edema]]
* [[Diuretics]]

== References ==
<references />

[[Category:Pharmacology]][[Category:Cardiology]][[Category:Renal]]

← Older revision		Revision as of 00:36, 28 January 2026
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	== See Also ==		== See Also ==
	* [[~~Heart Failure~~]]		* [[CHF]]
	* [[Pulmonary Edema]]		* [[Pulmonary Edema]]
	* [[Diuretics]]		* [[Diuretics]]