Humate-P - Revision history

Elcatracho: /* Indications */

2021-02-25T14:21:08Z

Indications

← Older revision		Revision as of 14:21, 25 February 2021
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	==Indications==		==Indications==
	*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)		*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
	*Von Willebrand disease that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)		*[[Von Willebrand disease]] that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)

	==Administration==		==Administration==

ClaireLewis at 19:28, 1 October 2019

2019-10-01T19:28:12Z

← Older revision		Revision as of 19:28, 1 October 2019
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	*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)		*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
	*Von Willebrand disease that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)		*Von Willebrand disease that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)

	~~==Contraindications==~~
	*Allergy to class/drug

	==Administration==		==Administration==
	*Type:		*Type: [[blood products]]
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration:
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	==Adult Dosing==		==Adult Dosing==
			*[[Von Willebrand disease]]
			**Major hemorrhage: loading dose 40-80 IU/kg IV
			**Minor hemorrhage: loading dose 40-50 IU/kg IV
			*[[Hemophilia]] A
			**Minor hemorrhage: Loading dose 15 IU/kg IV should achieve FVIII:C plasma level ~30% of normal
			**Moderate hemorrhage: Loading dose 25 IU/kg IV should achieve FVIII:C plasma level ~50% of normal
			**Life-threatening hemorrhage: 40-50 IU/kg IV initially, followed by 2-25 IU q8-12hr to maintain FVIII:C level at 80-100% of normal

	==Pediatric Dosing==		==Pediatric Dosing==
			*[[Von Willebrand disease]]
			**Major hemorrhage: loading dose 40-80 IU/kg IV
			**Minor hemorrhage: loading dose 40-50 IU/kg IV

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]: Data limited
	===Renal Dosing===		===Renal Dosing===
	*~~Adult:~~		*Not delineated
	*Pediatric:
	===Hepatic Dosing===		===Hepatic Dosing===
	*~~Adult:~~		*Not established
	*~~Pediatric:~~
			==Contraindications==
			*Allergy to class/drug

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Respiratory distress
			*Anaphylaxis
			*Thromboembolic events
			*Hemolytic anemia (in massive doses)

	===Common===		===Common===
			*Pain
			*Pruritus
			*Rash, urticaria, edema
			*Fever/chills, flu-like illness, cough, pharyngitis, rhinitis
			*Paresthesia
			*Fatigue
			*Headache
			*Asthenia
			*Cellulitis
			*Chest pain
			*Dyspepsia, nausea/vomiting
			*Hepatitis

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 10-11h
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion:

	==Mechanism of Action==		==Mechanism of Action==
			*Human derived vWF

	==Comments==		==Comments==
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	==See Also==		==See Also==
			*[[Hemophilia]]
			*[[VWD]]

	==References==		==References==

Mholtz at 00:28, 8 September 2016

2016-09-08T00:28:10Z

@@ Line 1: / Line 1: @@
-==Features==
+==Background==
-#Contains: vWF and factor VIII
+*Human Plasma-derived von Willebrand Factor
 ==Indications==
-#[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
+*[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
-#vWD that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)
+*Von Willebrand disease that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)
 ==See Also==
-*[[Transfusions]]
 ==References==
 <references/>
 [[Category:Pharmacology]]
 [[Category:Heme/Onc]]

Rossdonaldson1: Text replacement - "doesn't" to "does not"

2016-08-01T14:33:40Z

Text replacement - "doesn't" to "does not"

← Older revision		Revision as of 14:33, 1 August 2016
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	==Indications==		==Indications==
	#[[Hemophilia]] A (can also use factor VIII, [[FFP]] ~~doesn't~~ work well)		#[[Hemophilia]] A (can also use factor VIII, [[FFP]] does not work well)
	#vWD that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] ~~doesn't~~ work well)		#vWD that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] does not work well)

	==Dose==		==Dose==

Neil.m.young: Text replacement - "Tintinalli" to ""

2016-06-28T01:43:18Z

Text replacement - "Tintinalli" to ""

← Older revision		Revision as of 01:43, 28 June 2016
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	==References==		==References==
	<references/>		<references/>
	~~Tintinalli~~

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Neil.m.young: Text replacement - "==Source==" to "==References== "

2016-06-26T13:57:08Z

Text replacement - "==Source==" to "==References== <references/>"

← Older revision		Revision as of 13:57, 26 June 2016
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	*[[Transfusions]]		*[[Transfusions]]

	==~~Source~~==		==References==
			<references/>
	Tintinalli		Tintinalli

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:52:46Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:52, 22 March 2016
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	Tintinalli		Tintinalli

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Rossdonaldson1 at 08:09, 5 February 2014

2014-02-05T08:09:18Z

← Older revision		Revision as of 08:09, 5 February 2014
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	==Indications==		==Indications==
	#[[Hemophilia]] A (can also use factor VIII, [[FFP]] doesn't work well)		#[[Hemophilia]] A (can also use factor VIII, [[FFP]] doesn't work well)
	#vWD that is unresponsive to DDAVP (can also use ~~cryo~~, [[FFP]] doesn't work well)		#vWD that is unresponsive to DDAVP (can also use [[cryoprecipitate]], [[FFP]] doesn't work well)

	==Dose==		==Dose==

Rossdonaldson1: Created page with "==Features== #Contains: vWF and factor VIII ==Indications== #Hemophilia A (can also use factor VIII, FFP doesn't work well) #vWD that is unresponsive to DDAVP (can al..."

2014-02-05T08:07:36Z

Created page with "==Features== #Contains: vWF and factor VIII ==Indications== #Hemophilia A (can also use factor VIII, FFP doesn't work well) #vWD that is unresponsive to DDAVP (can al..."

New page

==Features==
#Contains: vWF and factor VIII

==Indications==
#[[Hemophilia]] A (can also use factor VIII, [[FFP]] doesn't work well)
#vWD that is unresponsive to DDAVP (can also use cryo, [[FFP]] doesn't work well)

==Dose==
Depends on condition and severity of bleeding

==See Also==
*[[Transfusions]]

==Source==
Tintinalli

[[Category:Drugs]]
[[Category:Heme/Onc]]