Emergency contraception - Revision history

Urinetrouble: Made sections more uniform, easier to read

2023-09-08T18:50:38Z

Made sections more uniform, easier to read

← Older revision		Revision as of 18:50, 8 September 2023
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	*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later
	**May also be taken as single dose (double dose)		**May also be taken as single dose (double dose)
	*Relative risk reduction of pregnancy = 89% (1% with vs 8% without)		*Relative risk reduction of pregnancy = 89% (1% with vs 8% without)
	**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>		**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>
			*Adverse effects: Nausea (23%), vomiting (6%)
	~~====~~Adverse ~~Reactions====~~
	*Nausea (23%)
	*Vomiting (6%)
	*No teratogenesis

	====Dosing====		====Dosing====
	*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill		*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill
	**Should be given as soon as possible after intercourse; labeled for use up to 72 hours post-coitus, however may still be moderately effective up to 5 days after<ref>Practice Bulletin No. 152: Emergency Contraception. Obstet Gynecol. 2015 Sep;126(3):e1-e11. doi: 10.1097/AOG.0000000000001047. PMID: 26287787.</ref>		**Should be given as soon as possible after intercourse; labeled for use up to 72 hours post-coitus, however may still be moderately effective up to 5 days after<ref>Practice Bulletin No. 152: Emergency Contraception. Obstet Gynecol. 2015 Sep;126(3):e1-e11. doi: 10.1097/AOG.0000000000001047. PMID: 26287787.</ref>
	**[[~~levonorgestrel~~]] (Plan B and generics) 0.75mg PO Q12H x2 doses		**[[Levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses
	*May also be taken as one-time dose of levonorgestrel 1.5mg PO once		*May also be taken as one-time dose of levonorgestrel 1.5mg PO once

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	*May be given up to 120 hours later (but efficacy reduced)		*May be given up to 120 hours later (but efficacy reduced)
	*Reduces risk of pregnancy by 75% (2% with vs 8% without)		*Reduces risk of pregnancy by 75% (2% with vs 8% without)
			*Adverse effects: Nausea (50%), vomiting (20%)
	~~====~~Adverse ~~Reactions====~~
	*Nausea (50%)
	*Vomiting (20%)

	~~====Safety====~~
	*No teratogenic effect

	~~====Contraindications====~~
	*Pregnancy

	====FDA approved regimens====		====FDA approved regimens====

Urinetrouble: Reorganized, clarified

2023-09-08T18:45:46Z

Reorganized, clarified

@@ Line 5: / Line 5: @@
 #Progestin-only regimen
 #Combination estrogen-progestin regimen
 ==Progestin-only Regimen==
@@ Line 45: / Line 64: @@
 *Levlen, Levora, Lo/Ovral, Low-Ogestrel - 4 pills (120 ug ethiny estradiol/0.6mg levonorgestrel) per dose; repeat in 12h
 *Triphasil, Tri-Levlen, Trivora - 4 pills (120 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h
 ==See Also==

Urinetrouble at 18:37, 8 September 2023

2023-09-08T18:37:27Z

← Older revision		Revision as of 18:37, 8 September 2023
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	*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>		*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>

	==[[Copper IUD]]==		==Copper IUD==
	*Copper intrauterine device (Paragard) can be used as emergency contraception up to 120 hours after unprotected sex		*Copper intrauterine device (Paragard) can be used as emergency contraception up to 120 hours after unprotected sex
	*Advantages:		*Advantages:

Urinetrouble: Simplified, clarified

2023-09-08T18:35:30Z

Simplified, clarified

← Older revision		Revision as of 18:35, 8 September 2023
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	==~~Progestin~~ (~~[[levonorgestrel]]~~)-~~Only~~ Regimen==		==Overview==
	===General===		====Most to least effective<ref>ACOG. Emergency Contraception. https://www.acog.org/womens-health/faqs/emergency-contraception </ref>====
			#Copper IUD
			#Ulipristal (''Ella'')
			#Progestin-only regimen
			#Combination estrogen-progestin regimen

			==Progestin-only Regimen==
			====General====
	*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later
	**May also be taken as single dose (double dose)		**May also be taken as single dose (double dose)
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	**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>		**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>

	===Adverse Reactions===		====Adverse Reactions====
	*Nausea (23%)		*Nausea (23%)
	*Vomiting (6%)		*Vomiting (6%)
	*No teratogenesis		*No teratogenesis

	===Dosing===		====Dosing====
	*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill		*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill
	**Should be given as soon as possible after intercourse; labeled for use up to 72 hours post-coitus, however may still be moderately effective up to 5 days after<ref>Practice Bulletin No. 152: Emergency Contraception. Obstet Gynecol. 2015 Sep;126(3):e1-e11. doi: 10.1097/AOG.0000000000001047. PMID: 26287787.</ref>		**Should be given as soon as possible after intercourse; labeled for use up to 72 hours post-coitus, however may still be moderately effective up to 5 days after<ref>Practice Bulletin No. 152: Emergency Contraception. Obstet Gynecol. 2015 Sep;126(3):e1-e11. doi: 10.1097/AOG.0000000000001047. PMID: 26287787.</ref>
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	*May also be taken as one-time dose of levonorgestrel 1.5mg PO once		*May also be taken as one-time dose of levonorgestrel 1.5mg PO once

	==Yuzpe Regimen ~~(Combination OCPs~~)==		==Combination OCPs (AKA Yuzpe Regimen)==
	===General===		====General====
	*First dose within 72 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 72 hours after unprotected intercourse followed by second dose 12 hours later
	*May be given up to 120 hours later (but efficacy reduced)		*May be given up to 120 hours later (but efficacy reduced)
	*Reduces risk of pregnancy by 75% (2% with vs 8% without)		*Reduces risk of pregnancy by 75% (2% with vs 8% without)

	===Adverse Reactions===		====Adverse Reactions====
	*Nausea (50%)		*Nausea (50%)
	*Vomiting (20%)		*Vomiting (20%)

	===Safety===		====Safety====
	*No teratogenic effect		*No teratogenic effect

	===Contraindications===		====Contraindications====
	*Pregnancy		*Pregnancy

	===FDA approved regimens===		====FDA approved regimens====
	*Ovral, Ogestrel - 2 pills (100 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h		*Ovral, Ogestrel - 2 pills (100 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h
	*Alesse, Aviane, Levlite - 5 pills (100 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h		*Alesse, Aviane, Levlite - 5 pills (100 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h
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	*Triphasil, Tri-Levlen, Trivora - 4 pills (120 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h		*Triphasil, Tri-Levlen, Trivora - 4 pills (120 ug ethiny estradiol/0.5mg levonorgestrel) per dose; repeat in 12h

	==Ulipristal ~~acetate~~ (Ella)==		==Ulipristal (Ella)==
	*Progesterone-receptor modulator, effective up to 120 hours after unprotected sex		*Progesterone-receptor modulator, effective up to 120 hours after unprotected sex
	*May be more effective than levonorgestrel in overweight patients<ref>Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, Gainer E, Ulmann A. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84:363-7.</ref>		*May be more effective than levonorgestrel in overweight patients<ref>Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, Gainer E, Ulmann A. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84:363-7.</ref>
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	*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>		*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>

	==[[IUD]]==		==[[Copper IUD]]==
	*Copper intrauterine device (Paragard) can be used as emergency contraception up to 120 hours after unprotected sex		*Copper intrauterine device (Paragard) can be used as emergency contraception up to 120 hours after unprotected sex
	*Advantages:		*Advantages:

ClaireLewis: /* Dosing */

2021-04-17T03:05:31Z

Dosing

← Older revision		Revision as of 03:05, 17 April 2021
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	===Dosing===		===Dosing===
	*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill ~~(must~~ be given ~~within~~ 72 hours)		*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill
			**Should be given as soon as possible after intercourse; labeled for use up to 72 hours post-coitus, however may still be moderately effective up to 5 days after<ref>Practice Bulletin No. 152: Emergency Contraception. Obstet Gynecol. 2015 Sep;126(3):e1-e11. doi: 10.1097/AOG.0000000000001047. PMID: 26287787.</ref>
	**[[levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses		**[[levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses
	*May also be taken as one-time dose of levonorgestrel 1.5mg PO once		*May also be taken as one-time dose of levonorgestrel 1.5mg PO once

Hoxbox: /* Dosing */

2021-04-09T12:42:58Z

Dosing

← Older revision		Revision as of 12:42, 9 April 2021
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	===Dosing===		===Dosing===
	*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill		*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill (must be given within 72 hours)
	**[[levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses		**[[levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses
	*May also be taken as one-time dose of levonorgestrel 1.5mg PO once		*May also be taken as one-time dose of levonorgestrel 1.5mg PO once

Spenceemmett: /* Ulipristal acetate (Ella) */

2021-01-16T15:39:27Z

Ulipristal acetate (Ella)

← Older revision		Revision as of 15:39, 16 January 2021
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	*May be more effective than levonorgestrel in overweight patients<ref>Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, Gainer E, Ulmann A. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84:363-7.</ref>		*May be more effective than levonorgestrel in overweight patients<ref>Glasier A, Cameron ST, Blithe D, Scherrer B, Mathe H, Levy D, Gainer E, Ulmann A. Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel. Contraception. 2011;84:363-7.</ref>
	*30 mg PO in single dose		*30 mg PO in single dose
			*Safe in breast feeding women, but FDA recommends discarding breast milk for 24 hrs after taking
	*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>		*Adverse effects: Nausea (~13%), abdominal pain (8-15%), headache (19%)<ref>Micromedex</ref>

Jfang: Updated how levonorgestrel may be given

2020-01-24T22:13:16Z

Updated how levonorgestrel may be given

← Older revision		Revision as of 22:13, 24 January 2020
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	===General===		===General===
	*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later
	**~~may take both at once~~		**May also be taken as single dose (double dose)
	*Relative risk reduction of pregnancy = 89% (1% with vs 8% without)		*Relative risk reduction of pregnancy = 89% (1% with vs 8% without)
	**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>		**Effectiveness may be reduced in obese patients; some emerging evidence suggests doubling dose for obese patients<ref>Edelman A, Cherala G, Blue S, Erikson D, Jensen J. Impact of obesity on the pharmacokinetics of levonorgestrel-based emergency contraception: single and double dosing. Contraception. 2016 ;94:52-57.</ref>


	===Adverse Reactions===		===Adverse Reactions===
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	*No teratogenesis		*No teratogenesis

	===~~FDA approved regimens~~===		===Dosing===
	*Plan B (marketed specifically for emergency contraception) - ~~1 pill (~~0.75mg ~~levonorgestrel)~~ per ~~dose~~		*Plan B (marketed specifically for emergency contraception) - levonorgestrel 0.75mg PO per pill
	**[[levonorgestrel]] (Plan B and generics) 0.75mg ~~po q12h~~ x2		**[[levonorgestrel]] (Plan B and generics) 0.75mg PO Q12H x2 doses
			*May also be taken as one-time dose of levonorgestrel 1.5mg PO once

	==Yuzpe Regimen (Combination OCPs)==		==Yuzpe Regimen (Combination OCPs)==

ClaireLewis: /* Progestin ((levonorgestrel-Only Regimen */

2016-11-14T04:20:18Z

Progestin ((levonorgestrel-Only Regimen

← Older revision		Revision as of 04:20, 14 November 2016
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	==Progestin (([[levonorgestrel]]-Only Regimen==		==Progestin ([[levonorgestrel]])-Only Regimen==
	===General===		===General===
	*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later

ClaireLewis: /* Progestin-Only Regimen */

2016-11-14T04:19:13Z

Progestin-Only Regimen

← Older revision		Revision as of 04:19, 14 November 2016
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	==Progestin-Only Regimen==		==Progestin (([[levonorgestrel]]-Only Regimen==
	===General===		===General===
	*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later		*First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later
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	===FDA approved regimens===		===FDA approved regimens===
	*Plan B (marketed specifically for emergency contraception) - 1 pill (0.75mg levonorgestrel) per dose		*Plan B (marketed specifically for emergency contraception) - 1 pill (0.75mg levonorgestrel) per dose
	**levonorgestrel (Plan B and generics) 0.75mg po q12h x2		**[[levonorgestrel]] (Plan B and generics) 0.75mg po q12h x2

	==Yuzpe Regimen (Combination OCPs)==		==Yuzpe Regimen (Combination OCPs)==