https://wikem.org/w/index.php?action=history&feed=atom&title=Edrophonium 2026-04-19T03:15:46Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Edrophonium&diff=229359&oldid=prev 2019-09-22T19:09:15Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:09, 22 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l112">Line 112:</td> <td colspan="2" class="diff-lineno">Line 112:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Neurology]]</ins></div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Edrophonium&diff=145944&oldid=prev 2017-07-07T10:33:27Z

<p>Text replacement - &quot;prn&quot; to &quot;PRN&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:33, 7 July 2017</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l12">Line 12:</td> <td colspan="2" class="diff-lineno">Line 12:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Nondepolarizing neuromuscular blockade reversal</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Nondepolarizing neuromuscular blockade reversal</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**10 mg IV x1 dose</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**10 mg IV x1 dose</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>***Repeat dose <del style="font-weight: bold; text-decoration: none;">prn</del>. Max: 40mg</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>***Repeat dose <ins style="font-weight: bold; text-decoration: none;">PRN</ins>. Max: 40mg</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Myasthenia gravis]], diagnosis</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Myasthenia gravis]], diagnosis</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**2 mg IV x1dose</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**2 mg IV x1dose</div></td></tr> </table>

Mholtz https://wikem.org/w/index.php?title=Edrophonium&diff=121036&oldid=prev 2017-01-31T06:58:53Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Cholinesterase inhibitor<br /> *Dosage Forms: INJ<br /> *Routes of Administration: IV, IM<br /> *Common Trade Names: Enlon, Tensilon<br /> <br /> ==Adult Dosing==<br /> *Myasthenic crisis, diagnosis<br /> **1 mg IV x2 doses<br /> ***Max: 2 mg cumulative dose<br /> ***Give second dose 1 min later if no impairment due to 1st dose<br /> *Nondepolarizing neuromuscular blockade reversal<br /> **10 mg IV x1 dose<br /> ***Repeat dose prn. Max: 40mg<br /> *[[Myasthenia gravis]], diagnosis<br /> **2 mg IV x1dose<br /> ***If no cholinergic rxn after 45s, give 8 mg IV x1 dose<br /> ***Give atropine sulfate 0.4-0.5 mg IV x1 dose if rxn from 2 mg edrophonium dose<br /> **10 mg IM x1 dose<br /> ***If cholinergic rxn, give 2 mg IM x1 dose 30 min after 1st dose<br /> *[[Myasthenia gravis]], tx evaluation<br /> **1-2 mg IV x1 dose<br /> ***1h after PO tx drug<br /> <br /> ==Pediatric Dosing==<br /> *[[Myasthenia gravis]], diagnosis<br /> **Infants<br /> ***0.5 mg IV x1 dose<br /> **&lt;75 lb<br /> ***1 mg IV x1 dose<br /> ****Max: 5 mg cumulative dose<br /> ****Alt: 5 mg IM x1 dose<br /> **&gt;75 lb<br /> ***2 mg IV x1 dose<br /> ****Max: 10 mg cumulative dose<br /> ****Alt: 5 mg IM x1 dose<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: C; Caution advised in pregnancy, esp. in 3rd trimester<br /> *Lactation risk: Probably safe; Limited information demonstrates no risk. Caution advised.<br /> <br /> ===Renal Dosing===<br /> *Adult: Not defined<br /> *Pediatric: Not defined<br /> ===Hepatic Dosing===<br /> *Adult: Not defined<br /> *Pediatric: Not defined<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *GI obstruction<br /> *Urinary obstruction<br /> *Caution if hypersensitivity to sulfites<br /> *Caution if asthma<br /> *Caution if arrhythmias<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Cholinergic rxn, severe<br /> *[[Arrhythmia]]<br /> *[[Bradycardia]]<br /> *[[Hypotension]]<br /> *Resp. Paralysis<br /> *[[Seizure]]<br /> *Laryngospasm<br /> *Bronchospasm<br /> <br /> ===Common===<br /> *Lacrimation<br /> *Miosis<br /> *Accommodation spasm<br /> *[[Diplopia]]<br /> *Hyperemia, conjuntival<br /> *[[Seizure]]<br /> *[[Dysarthria]]<br /> *[[Dysphonia]]<br /> *[[Dysphagia]]<br /> *Increased pulmonary secretions<br /> *Laryngospasm<br /> *Bronchospasm<br /> *Resp. Paralysis<br /> *[[Arrhythmia]]<br /> *[[Bradycardia]]<br /> *[[Hypotension]]<br /> *Increased GI secretions<br /> *[[Nausea]]/[[Vomiting]]<br /> *[[Diarrhea]]<br /> *Abdominal cramps<br /> *[[Weakness]]<br /> *Fasciculation<br /> *Urinary frequency<br /> *Incontinence<br /> *Diaphoresis<br /> <br /> ==Pharmacology==<br /> *Half-life: 33-110 min<br /> *Metabolism: Unknown<br /> *Excretion: Urine<br /> <br /> ==Mechanism of Action==<br /> Reversibly binds to and inactivates acetylcholinesterases.<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> *[[Myasthenia gravis]]<br /> *[[Acetylcholinesterase inhibitor]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren