EBQ:Cephalosporin Cross-reactivity - Revision history

Danbot: Added all standard JC sections

2026-03-21T22:50:54Z

Added all standard JC sections

@@ Line 13: / Line 13: @@
 ==External Links==
 *[https://umem.org/educational_pearls/2540/ UMEM - Penicillin Cephalosporin Cross-Reactivity Made Easy]
 ==See Also==

Rossdonaldson1: /* Cross-Reaction Risk */

2019-03-26T16:40:25Z

Cross-Reaction Risk

← Older revision		Revision as of 16:40, 26 March 2019
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	* Cross-reactivity between [[penicillins]] and 1st and 2nd generation [[cephalosporins]] is possible.<ref name="campagna"></ref>		* Cross-reactivity between [[penicillins]] and 1st and 2nd generation [[cephalosporins]] is possible.<ref name="campagna"></ref>
	* Cross-reactivity between [[penicillins]] and ALL 3rd and 4th generation [[cephalosporins]] is negligible.<ref name="campagna"></ref>		* Cross-reactivity between [[penicillins]] and ALL 3rd and 4th generation [[cephalosporins]] is negligible.<ref name="campagna"></ref>

	~~;If a patient has an allergy to [[amoxicillin]] or [[ampicillin]], avoid [[cefadroxil]], [[cefaclor]], [[cefatrizine]], [[cefprozil]], [[cephalexin]], and [[cephradine]].~~

	==Antibiotic Categories==		==Antibiotic Categories==

Rossdonaldson1: /* Background */

2019-03-26T16:39:25Z

Background

← Older revision		Revision as of 16:39, 26 March 2019
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	==Background==		==Background==
	Previously, [[penicillins~~\|Penicillins~~]] (PCN) and [[cephalosporins]] were produced with the same fungi during synthesis. This increased the rate of cross contamination especially prior to 1980. Although the allergy was though to be due to the similarities in the beta-lactam ring it is more probably caused due to manufacturing contamination although there is cross reactivity risk based on side chain similarity. 1st and 2nd generation [[penicillins]] share the same R-1 side chain.<ref>UIC Pharmacology on Penicillin Cross Reactivity https://www.uic.edu/pharmacy/services/di/crossens.htm</ref> However, a current review of the literature demonstrates that the 10% or greater allergy may be exaggerated.<ref name="campagna">Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: A literature review. J Emerg Med. 2012;42(5):612-20</ref>		Previously, [[penicillins]] (PCN) and [[cephalosporins]] were produced with the same fungi during synthesis. This increased the rate of cross contamination especially prior to 1980. Although the allergy was though to be due to the similarities in the beta-lactam ring it is more probably caused due to manufacturing contamination although there is cross reactivity risk based on side chain similarity. 1st and 2nd generation [[penicillins]] share the same R-1 side chain.<ref>UIC Pharmacology on Penicillin Cross Reactivity https://www.uic.edu/pharmacy/services/di/crossens.htm</ref> However, a current review of the literature demonstrates that the 10% or greater allergy may be exaggerated.<ref name="campagna">Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: A literature review. J Emerg Med. 2012;42(5):612-20</ref>

	* 1st generation [[cephalosporins]]: [[cefadroxil]], [[cefatrizine]], [[cephalexin]], cephradine
	* 2nd generation c[[ephalosporins]]: [[cefaclor]], [[cefprozil]]

	==Cross-Reaction Risk==		==Cross-Reaction Risk==

Rossdonaldson1: /* Antibiotic Categories */

2019-03-26T16:38:27Z

Antibiotic Categories

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 ==Antibiotic Categories==
-{{Cephalosporin Cross-reactivity}}
+{{Beta-lactams}}
 ==External Links==

Rossdonaldson1: /* Antibiotic Categories */

2019-03-26T16:37:26Z

Antibiotic Categories

← Older revision		Revision as of 16:37, 26 March 2019
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	==Antibiotic Categories==		==Antibiotic Categories==
	{{Cephalosporin Cross-reactivity ~~\|state=collapsed~~}}		{{Cephalosporin Cross-reactivity}}



	{{Navbox		{{Navbox
	\| name = ~~Clinically Utilized Antibiotics~~		\| name = Beta-lactams
	\| title = ~~Clinically Utilized [[Antibiotics]]~~		\| title = Beta-lactams
	\| state = {{{state\|autocollapse}}}		\| state = {{{state\|autocollapse}}}
	\|listclass = hlist		\|listclass = hlist

Rossdonaldson1: /* Antibiotic Categories */

2019-03-26T16:36:02Z

Antibiotic Categories

← Older revision		Revision as of 16:36, 26 March 2019
Line 14:		Line 14:

	==Antibiotic Categories==		==Antibiotic Categories==
			{{Cephalosporin Cross-reactivity \|state=collapsed}}

	{{Navbox		{{Navbox
	\| name = Clinically Utilized Antibiotics		\| name = Clinically Utilized Antibiotics

Rossdonaldson1 at 16:33, 26 March 2019

2019-03-26T16:33:57Z

← Older revision		Revision as of 16:33, 26 March 2019
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	;If a patient has an allergy to [[amoxicillin]] or [[ampicillin]], avoid [[cefadroxil]], [[cefaclor]], [[cefatrizine]], [[cefprozil]], [[cephalexin]], and [[cephradine]].		;If a patient has an allergy to [[amoxicillin]] or [[ampicillin]], avoid [[cefadroxil]], [[cefaclor]], [[cefatrizine]], [[cefprozil]], [[cephalexin]], and [[cephradine]].

			==Antibiotic Categories==
			{{Navbox
			\| name = Clinically Utilized Antibiotics
			\| title = Clinically Utilized [[Antibiotics]]
			\| state = {{{state\|autocollapse}}}
			\|listclass = hlist
			\| groupstyle = background:PowderBlue;

			\|group1 = [[β-lactams]]
			\|list1 = {{Navbox subgroup
			\| groupstyle = background:PowderBlue;

			\| group1 = [[Penicillins]]
			\| list1 = {{Navbox subgroup
			\| groupstyle = background:PowderBlue;

			\| group1 = Natural
			\| list1 =
			* [[Penicillin G]]
			* [[Penicillin V]]

			\| group2 = Anti-Staphylococcal
			\| list2 =
			* [[Cloxacillin]]
			* [[Dicloxacillin]]
			* [[Oxacillin]]
			* [[Nafcillin]]

			\| group3 = Amino-Penicillins
			\| list3 =
			* [[Amoxicillin]]
			* [[Ampicillin]]
			* [[Amoxicillin/Clavulanate]]
			* [[Ampicillin/Sulbactam]]

			\| group4 = Anti-Pseudomonal
			\| list4 =
			* [[Piperacillin/Tazobactam]]
			* [[Ticarcillin/Clavulanate]]

			}}

			\| group3 = [[Carbapenems]]
			\| list3 =
			* [[Ertapenem]]
			* [[Doripenem]]
			* [[Imipenem/Cilastin]]
			* [[Meropenem]]
			\| groupstyle = background-color: PowderBlue

			\| group4= [[Cephalosporins]]
			\| list4= {{Navbox subgroup
			\| groupstyle = background-color: PowderBlue

			\| group1 = 1st
			\| list1 =
			* [[Cefazolin]] (Ancef)
			* [[Cefadroxil]]
			* [[Cephalexin]] (Keflex)

			\| group2= 2nd
			\| list2=
			* [[Cefuroxime]]
			* [[Cefoxitin]]
			* [[Cefotetan]]
			* [[Cefaclor]]
			* [[Cefprozil]]

			\| group3= 3rd
			\| list3=
			*[[Cefdinir]]
			*[[Cefixime]]
			*[[Cefotaxime]]
			*[[Cefpodoxime]]
			*[[Ceftriaxone]]
			*[[Ceftazidime]]
			*[[Cefditoren]]
			*[[Ceftibuten]]

			\| group4= 4th (antipseudomonal)
			\| list4=
			* [[Cefepime]]

			\| group5= 5th
			\| list5=
			* [[Ceftaroline fosamil]] (Teflaro)

			}}

			\| group5 = Monobactams
			\| list5 =
			* [[Aztreonam]]

			}}

			}}<noinclude>
			{{collapsible option}}

			</noinclude>

	==External Links==		==External Links==

Rossdonaldson1: /* Campagna Review Article */

2019-03-26T16:28:45Z

Campagna Review Article

← Older revision		Revision as of 16:28, 26 March 2019
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	* 2nd generation c[[ephalosporins]]: [[cefaclor]], [[cefprozil]]		* 2nd generation c[[ephalosporins]]: [[cefaclor]], [[cefprozil]]

	== ~~Campagna Review Article~~==		==Cross-Reaction Risk==
	* Overall cross-reactivity rate between [[cephalosporins]] and [[penicillins]] in patients reporting a penicillin allergy = 1%. <ref name="campagna"></ref>		* Overall cross-reactivity rate between [[cephalosporins]] and [[penicillins]] in patients reporting a penicillin allergy = 1%. <ref name="campagna"></ref>
	* Overall cross-reactivity rate in patients with a confirmed penicillin allergy = 2.5%.		* Overall cross-reactivity rate in patients with a confirmed penicillin allergy = 2.5%. <ref name="campagna"></ref>
	* Cross-reactivity between [[penicillins]] and 1st and 2nd generation [[cephalosporins]] is possible.		* Cross-reactivity between [[penicillins]] and 1st and 2nd generation [[cephalosporins]] is possible.<ref name="campagna"></ref>
	* Cross-reactivity between [[penicillins]] and ALL 3rd and 4th generation [[cephalosporins]] is negligible.		* Cross-reactivity between [[penicillins]] and ALL 3rd and 4th generation [[cephalosporins]] is negligible.<ref name="campagna"></ref>

	;If a patient has an allergy to [[amoxicillin]] or [[ampicillin]], avoid [[cefadroxil]], [[cefaclor]], [[cefatrizine]], [[cefprozil]], [[cephalexin]], and [[cephradine]].		;If a patient has an allergy to [[amoxicillin]] or [[ampicillin]], avoid [[cefadroxil]], [[cefaclor]], [[cefatrizine]], [[cefprozil]], [[cephalexin]], and [[cephradine]].

Rossdonaldson1 at 16:22, 26 March 2019

2019-03-26T16:22:46Z

← Older revision		Revision as of 16:22, 26 March 2019
Line 1:		Line 1:
	[[penicillins\|Penicillins]] (PCN) and [[cephalosporins]] were produced with the same fungi during synthesis. This increased the rate of cross contamination especially prior to 1980. Although the allergy was though to be due to the similarities in the beta-lactam ring it is more probably caused due to manufacturing contamination although there is cross reactivity risk based on side chain similarity. 1st and 2nd generation [[penicillins]] share the same R-1 side chain.<ref>UIC Pharmacology on Penicillin Cross Reactivity https://www.uic.edu/pharmacy/services/di/crossens.htm</ref> However, a current review of the literature demonstrates that the 10% or greater allergy may be exaggerated.<ref name="campagna">Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: A literature review. J Emerg Med. 2012;42(5):612-20</ref>		==Background==
			Previously, [[penicillins\|Penicillins]] (PCN) and [[cephalosporins]] were produced with the same fungi during synthesis. This increased the rate of cross contamination especially prior to 1980. Although the allergy was though to be due to the similarities in the beta-lactam ring it is more probably caused due to manufacturing contamination although there is cross reactivity risk based on side chain similarity. 1st and 2nd generation [[penicillins]] share the same R-1 side chain.<ref>UIC Pharmacology on Penicillin Cross Reactivity https://www.uic.edu/pharmacy/services/di/crossens.htm</ref> However, a current review of the literature demonstrates that the 10% or greater allergy may be exaggerated.<ref name="campagna">Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: A literature review. J Emerg Med. 2012;42(5):612-20</ref>

	* 1st generation [[cephalosporins]]: [[cefadroxil]], [[cefatrizine]], [[cephalexin]], cephradine		* 1st generation [[cephalosporins]]: [[cefadroxil]], [[cefatrizine]], [[cephalexin]], cephradine

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:03Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:54, 22 March 2016
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	[[Category:EBQ]]		[[Category:EBQ]]
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]