Ostermayer at 19:34, 28 January 2026

2026-01-28T19:34:09Z

← Older revision		Revision as of 19:34, 28 January 2026
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	~~Here is the Wikitext formatted for the antibiotic Cefetamet (specifically the prodrug Cefetamet pivoxil), mirroring the structure and style of the example provided.~~

	~~```mediawiki~~
	==General==		==General==
	*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]		*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]

Ostermayer: Created page with "Here is the Wikitext formatted for the antibiotic Cefetamet (specifically the prodrug Cefetamet pivoxil), mirroring the structure and style of the example provided. ```mediawiki ==General== Type: Is Generation::3rd generation Is DrugClass::Cephalosporin Dosage Forms: Tablet, Powder for oral suspension Dosage Strengths: 250mg, 500mg (dosed as cefetamet pivoxil) Routes of Administration: PO Common Trade Names: Globor ==Adult Dosing== ===General=== S..."

2026-01-28T19:33:12Z

Created page with "Here is the Wikitext formatted for the antibiotic **Cefetamet** (specifically the prodrug **Cefetamet pivoxil**), mirroring the structure and style of the example provided. ```mediawiki ==General== *Type: Is Generation::3rd generation Is DrugClass::Cephalosporin *Dosage Forms: Tablet, Powder for oral suspension *Dosage Strengths: 250mg, 500mg (dosed as cefetamet pivoxil) *Routes of Administration: PO *Common Trade Names: Globor ==Adult Dosing== ===General=== *S..."

New page

Here is the Wikitext formatted for the antibiotic **Cefetamet** (specifically the prodrug **Cefetamet pivoxil**), mirroring the structure and style of the example provided.

```mediawiki
==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: Tablet, Powder for oral suspension
*Dosage Strengths: 250mg, 500mg (dosed as cefetamet pivoxil)
*Routes of Administration: PO
*Common Trade Names: Globor

==Adult Dosing==
===General===
*Standard: 500mg PO q12h
*Administer with food (increases bioavailability)
*Max: 2000mg/day

===Community Acquired [[Pneumonia]]===
*500mg PO q12h x 10 days

===Acute Bacterial Exacerbation of Chronic [[Bronchitis]]===
*500mg PO q12h x 7 days

===Acute [[Sinusitis]] / [[Pharyngitis]]===
*500mg PO q12h x 7-10 days

===[[UTI]], Complicated and Uncomplicated===
*500mg PO q12h x 7-10 days

===Uncomplicated [[Gonorrhea]]===
*1200-1500mg PO x 1 (Single dose)

==Pediatric Dosing==
===General (>3 Months)===
*10mg/kg PO q12h
*Administer with food
*Max: 1000mg/day (Administer as tablet if child can swallow, or suspension)

===Acute [[Otitis Media]]===
*10mg/kg PO q12h x 7-10 days

===[[Pharyngitis]] / Tonsillitis===
*10mg/kg PO q12h x 7-10 days

==Special Populations==
*Pregnancy: B (Use only if clearly needed)
*Lactation: Excreted in breast milk; caution advised
*Renal
**Adult
***CrCl > 40: Standard dose (500mg q12h)
***CrCl 10-39: 125mg q12h OR 500mg q24h
***CrCl < 10: 125mg q24h OR 500mg q48h
***Hemodialysis: Give supplement after dialysis
**Pediatric
***CrCl > 40: Standard dose
***CrCl < 40: Extend interval or reduce dose similar to adult proportions
*Hepatic
**No adjustment necessary (metabolism is ester hydrolysis in intestinal wall/serum, not hepatic CYP dependent)

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of severe hypersensitivity to Penicillin
*Known Carnitine deficiency (due to pivoxil pivalate liberation)

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]] associated diarrhea
*Hypocarnitinemia (Long term use)
*[[Angioedema]]

===Common===
*[[Diarrhea]]
*[[Nausea and Vomiting]]
*[[Abdominal Pain]]
*Dyspepsia
*Headache
*Fatigue

==Pharmacology==
*Half-life: 2-3h (Prolonged in renal impairment)
*Metabolism: Cefetamet pivoxil is a prodrug; hydrolyzed by esterases in the intestinal wall to active Cefetamet (and pivalic acid).
*Excretion: Urine (>85% as unchanged active drug)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Notes: Poor activity against Staphylococci compared to other cephalosporins.

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||R
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||R
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||I
|-
| ||Serratia marcescens||I
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||I
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||I
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]
```

Cefetamet - Revision history

Ostermayer at 19:34, 28 January 2026