Ostermayer at 17:20, 27 January 2026

2026-01-27T17:20:13Z

Ostermayer: Created page with "== General == * '''Class''': First-generation Cephalosporin antibiotic [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium) * '''Chemical Structure''': Contains Isonicotinamides, Thiophenes, and Pyridinium compounds [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium) * '''Usage''': Primarily used in veterinary medicine (specifically broadly used for mastitis in cattle and ophthalmic infections in biochemical research). == Dosing == === H..."

2026-01-27T17:13:48Z

Created page with "== General == * '''Class''': First-generation Cephalosporin antibiotic [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium) * '''Chemical Structure''': Contains Isonicotinamides, Thiophenes, and Pyridinium compounds [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium) * '''Usage''': Primarily used in veterinary medicine (specifically broadly used for mastitis in cattle and ophthalmic infections in biochemical research). == Dosing == === H..."

New page

== General ==
* '''Class''': First-generation [[Cephalosporin]] antibiotic [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)
* '''Chemical Structure''': Contains [[Isonicotinamides]], [[Thiophenes]], and [[Pyridinium compounds]] [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)
* '''Usage''': Primarily used in veterinary medicine (specifically broadly used for mastitis in cattle and ophthalmic infections in biochemical research).

== Dosing ==
=== Human ===
* '''Systemic''': Not currently indicated for human clinical use.
* '''Note''': Cefalonium is almost exclusively utilized in veterinary contexts, particularly for "dry cow" therapy (intramammary infusion) or topical ophthalmic preparations in animals.

== Pharmacology ==
=== Mechanism of Action ===
Like other cephalosporins, Cefalonium is a bactericidal agent. It acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the final transpeptidation step of peptidoglycan synthesis.

=== Chemical Data ===
* '''Type''': Beta-lactam antibiotic
* '''Generation''': First-generation
* '''Related Compounds''': Structurally similar to other broad-spectrum cephalosporins containing thiophene rings.

== Antibiotic Sensitivities ==
As a first-generation cephalosporin, Cefalonium exhibits activity primarily against Gram-positive bacteria and a limited range of Gram-negative bacteria.

{| class="wikitable"
! Group !! Organism !! Sensitivity
|-
| rowspan="3" | '''Gram Positive'''
| [[Staphylococcus aureus]] (MSSA) || '''S'''
|-
| [[Streptococcus agalactiae]] || '''S'''
|-
| [[Streptococcus dysgalactiae]] || '''S'''
|-
| rowspan="2" | '''Gram Negative'''
| [[Escherichia coli]] || '''S'''/I
|-
| [[Corynebacterium]] spp. || '''S'''
|}
'''Key''': '''S''' = Susceptible, '''I''' = Intermediate, '''R''' = Resistant

== References ==
* Wikipedia contributors. "Cefalonium." Wikipedia, The Free Encyclopedia. [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)

[[Category:Pharmacology]]
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Cefalonium - Revision history

Ostermayer at 17:20, 27 January 2026