Biologic immunomodulators - Revision history

Danbot: Reduce excessive bold: 13 -> 0 instances

2026-03-22T08:46:19Z

Reduce excessive bold: 13 -> 0 instances

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	The various letters chosen in the name indicated the structure, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.<ref>https://www.who.int/medicines/services/inn/StemBook2009.pdf</ref>		The various letters chosen in the name indicated the structure, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.<ref>https://www.who.int/medicines/services/inn/StemBook2009.pdf</ref>
	===Suffix===		===Suffix===
	*~~'''~~-mab~~'''~~ means a monoclonal antibody		*-mab means a monoclonal antibody
	*~~'''~~–cept~~'''~~ indicates a protein that mimics an immunoglobulin.		*–cept indicates a protein that mimics an immunoglobulin.
	===Middle syllable===		===Middle syllable===
	*~~'''~~–u-~~'''~~ means all human derived		*–u- means all human derived
	*~~'''~~-o-~~'''~~ means all mouse derived		*-o- means all mouse derived
	*~~'''~~-zu-~~'''~~ means humanized after being mouse derived		*-zu- means humanized after being mouse derived
	*~~'''~~–xi-~~'''~~ means part-human and part-non human.		*–xi- means part-human and part-non human.
	===Middle bridging syllable===		===Middle bridging syllable===
	This lettering can indicate the biologic's target		This lettering can indicate the biologic's target
	*~~'''~~t-~~'''~~ means tumor is the target.		*t- means tumor is the target.
	*~~'''~~–ba-~~'''~~ means there is bacterium target.		*–ba- means there is bacterium target.
	*~~'''~~–so-~~'''~~ means bone is targeted.		*–so- means bone is targeted.
	*~~'''~~–ci-~~'''~~ targets circulation.		*–ci- targets circulation.
	*~~'''~~–fu-~~'''~~ targets fungus.		*–fu- targets fungus.
	*~~'''~~–gro-~~'''~~ targets growth factor.		*–gro- targets growth factor.
	*~~'''~~–ki- or –li-~~'''~~ which means it is interleukin or immune targeted.		*–ki- or –li- which means it is interleukin or immune targeted.

	==Adverse events==		==Adverse events==

Elcatracho: /* Special considerations */

2021-03-08T20:04:28Z

Special considerations

← Older revision		Revision as of 20:04, 8 March 2021
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	==Special considerations==		==Special considerations==
	*No live vaccines should be given to these patients.		*No live [[Vaccination schedule\|vaccines]] should be given to these patients.


	==References==		==References==

Ostermayer: /* Adverse events */

2020-03-04T17:28:10Z

Adverse events

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 ==Adverse events==
-*Decreased cellular immunity which an cause reactivation or new
+{{oncologic therapy adverse events}}
-**[[Tuberculosis]]
 ==Special considerations==
 *No live vaccines should be given to these patients.

ClaireLewis at 21:34, 19 September 2019

2019-09-19T21:34:27Z

← Older revision		Revision as of 21:34, 19 September 2019
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	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:Rheumatology]]

Ostermayer: /* Naming */

2019-06-21T13:45:01Z

Naming

← Older revision		Revision as of 13:45, 21 June 2019
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	==Naming==		==Naming==
	The various letters chosen in the name indicated the structure, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.		The various letters chosen in the name indicated the structure, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.<ref>https://www.who.int/medicines/services/inn/StemBook2009.pdf</ref>
	===Suffix===		===Suffix===
	*'''-mab''' means a monoclonal antibody		*'''-mab''' means a monoclonal antibody

Ostermayer: /* Background */

2019-06-21T13:44:16Z

Background

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	==Background==		==Background==
	*Immunomodulators created by a mouse or human cell that either create antibodies or targets against various cell lines that are receptor based. They interact with cellular immunity such as tumor necrosis factor alpha and interleukins.		*Immunomodulators created by a mouse or human cell that either create antibodies<ref>https://www.ama-assn.org/sites/ama-assn.org/files/corp/media-browser/public/usan/usan-previous-monoclonal-antibodies-policy.pdf</ref> or targets against various cell lines that are receptor based. They interact with cellular immunity such as tumor necrosis factor alpha and interleukins.
	*The agent's uses range from a wide array of indications such as [[Crohn's disease]], [[Ulcerative colitis]] and [[Inflammatory bowel disease]], [[Rheumatoid arthritis]], [[Psoriatic arthritis]], [[Ankylosing spondylitis]] and many malignancies with specific receptors.		*The agent's uses range from a wide array of indications such as [[Crohn's disease]], [[Ulcerative colitis]] and [[Inflammatory bowel disease]], [[Rheumatoid arthritis]], [[Psoriatic arthritis]], [[Ankylosing spondylitis]] and many malignancies with specific receptors.

Ostermayer: /* Naming */

2019-06-20T19:28:00Z

Naming

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	==Naming==		==Naming==
	The ~~variious~~ letters chosen in the name indicated the ~~strucutre~~, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.		The various letters chosen in the name indicated the structure, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.
	===Suffix===		===Suffix===
	*'''-mab''' means a monoclonal antibody		*'''-mab''' means a monoclonal antibody

Ostermayer: Created page with "==Background== *Immunomodulators created by a mouse or human cell that either create antibodies or targets against various cell lines that are receptor based. They interact wi..."

2019-06-20T19:24:45Z

Created page with "==Background== *Immunomodulators created by a mouse or human cell that either create antibodies or targets against various cell lines that are receptor based. They interact wi..."

New page

==Background==
*Immunomodulators created by a mouse or human cell that either create antibodies or targets against various cell lines that are receptor based. They interact with cellular immunity such as tumor necrosis factor alpha and interleukins.
*The agent's uses range from a wide array of indications such as [[Crohn's disease]], [[Ulcerative colitis]] and [[Inflammatory bowel disease]], [[Rheumatoid arthritis]], [[Psoriatic arthritis]], [[Ankylosing spondylitis]] and many malignancies with specific receptors.

==Naming==
The variious letters chosen in the name indicated the strucutre, origin, and targets of the molecule. For example ixekizumab for psoriasis ends with –mab, so it is a monoclonal antibody, has a –u- so it is human and has –ki- which means that it is interleukin targeted.
===Suffix===
*'''-mab''' means a monoclonal antibody
*'''–cept''' indicates a protein that mimics an immunoglobulin.
===Middle syllable===
*'''–u-''' means all human derived
*'''-o-''' means all mouse derived
*'''-zu-''' means humanized after being mouse derived
*'''–xi-''' means part-human and part-non human.
===Middle bridging syllable===
This lettering can indicate the biologic's target
*'''t-''' means tumor is the target.
*'''–ba-''' means there is bacterium target.
*'''–so-''' means bone is targeted.
*'''–ci-''' targets circulation.
*'''–fu-''' targets fungus.
*'''–gro-''' targets growth factor.
*'''–ki- or –li-''' which means it is interleukin or immune targeted.

==Adverse events==
*Decreased cellular immunity which an cause reactivation or new
**[[Tuberculosis]]
**[[Sepsis]]
**[[Fungal infections]]
**[[Hepatitis B]]
*Neurologic syndromes
**[[Multiple sclerosis]]
**[[Seizures]]
**[[Guillain-Barre syndrome]]
*Hematologic side effects
**[[Aplastic anemia]]
**[[Pancytopenia]]
*Cardiac effects
**[[Congestive heart failure]]
**[[Arrhythmias]]
*[[Allergic reactions]]
*Pulmonary
**[[Pneumonia]]
**[[Pneumocystis jirovecii pneumonia]]
**[[Pneumonitis]]
*Endocrine
**[[Thyroiditis]]
*GI
**Perforations
**[[Clostridium difficile]]
**Acute bacterial infections
*Malignancies
**Non-melanoma skin cancers
**Lymphoma
==Special considerations==
*No live vaccines should be given to these patients.

==References==
<references/>

[[Category:Pharmacology]]