https://wikem.org/w/index.php?action=history&feed=atom&title=Barbiturate_withdrawalBarbiturate withdrawal - Revision history2026-05-08T15:11:23ZRevision history for this page on the wikiMediaWiki 1.38.2https://wikem.org/w/index.php?title=Barbiturate_withdrawal&diff=110138&oldid=prevClaireLewis: Created page with "==Background== *Presentation similar to alcohol withdrawal *Tolerance and dependence on barbiturates develops rapidly ==Clinical Features== *Onset of minor symptoms with..."2016-11-11T20:36:15Z<p>Created page with "==Background== *Presentation similar to alcohol withdrawal *Tolerance and dependence on <a href="/wiki/Barbiturates" title="Barbiturates">barbiturates</a> develops rapidly ==Clinical Features== *Onset of minor symptoms with..."</p>
<p><b>New page</b></p><div>==Background==<br />
*Presentation similar to alcohol withdrawal<br />
*Tolerance and dependence on [[barbiturates]] develops rapidly <br />
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==Clinical Features==<br />
*Onset of minor symptoms within 24h of abrupt cessation<br />
*Major, life-threatening symptoms occur ~2-8 days after stopping drug<br />
*Symptoms more severe with higher dose, longer duration of use, and use of short-acting barbiturates<br />
*Autonomic hyperactivity (e.g., diaphoresis, HR>100, hyperthermia)<br />
*[[Nausea/vomiting]], abdominal cramping<br />
*Tremulousness, psychomotor agitation, muscle twitching<br />
*Anxiety, insomnia, irritability agitation<br />
*[[Psychosis]] (more common than in ETOH withdrawal)<br />
*Seizure<br />
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==Differential Diagnosis==<br />
{{Sedative/hypnotic withdrawal types}}<br />
{{Seizure DDX}}<br />
{{AMS DDX}}<br />
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==Evaluation==<br />
*Evaluate for other causes of and complications of symptoms (see evaluation of [[seizure]], [[altered mental status]], [[hypertension]], [[hyperthermia]]<br />
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==Management==<br />
*Ensure patient and staff safety, airway protection if acutely agitated or seizing<br />
*Seizures can be treated with [[benzodiazepines]], but management with barbiturates (e.g. [[phenobarbital]]) generally more effective<br />
*Generally need gradual detox as inpatient<br />
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==Disposition==<br />
*Admit for gradual detoxification<br />
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==See Also==<br />
*[[Barbiturates]], [[Barbiturate toxicity]]<br />
*[[ETOH withdrawal]], [[benzodiazepine withdrawal]]<br />
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==External Links==<br />
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==References==<br />
<references/><br />
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[[Category:Toxicology]]</div>ClaireLewis