View source for Tirofiban

==Administration==
*Type: [[Antiplatelet]]
*Dosage Forms: INJ
*Routes of Administration: IV
*Common Trade Names: Aggrastat

==Adult Dosing==
===[[Acute coronary syndrome]], Non ST-elevation===
*25 mcg/kg IV x1, then 0.15 mcg/kg/min IV for up to 18h

==Pediatric Dosing==
Safety/efficacy not established in pediatric patients

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Category B
*Benefits outweigh risks during pregnancy
*Risk of maternal hemorrhage during delivery
*Risk of fetal bleeding

===Lactation risk===
*Caution advised while breastfeeding

===Renal Dosing===
*Adult:
**CrCl <60: Decrease maintenance infusion rate 50%
**HD: Not defined
*Pediatric: Unavailable

===Hepatic Dosing===
*Adult: Not defined
*Pediatric: Unavailable

==Contraindications==
*Allergy to class/drug
*[[Thrombocytopenia]] with prior use
*Active bleeding
*Coagulation disorder w/in 30 days
*Major trauma or surgery w/in 30 days

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*Bleeding, severe
*[[Intracranial hemorrhage]]
*Intraocular hemorrhage
*Retroperitoneal bleeding
*[[Thrombocytopenia]], severe
*[[Coronary artery dissection]]

===Common===
*Bleeding
*Pelvic pain
*[[Bradycardia]]
*Edema, Leg pain
*[[Dizziness]], Diaphoresis

==Pharmacology==
*Half-life: 2 hour
*Metabolism: Minimal
*Excretion: Urine 65%, feces 25% (primarily unchanged)

==Mechanism of Action==
*Reversibly binds to platelet glycoprotein IIb/IIIa receptors, reducing platelet aggregation

==Comments==


==See Also==
*[[Antiplatelet medications]]
*[[Antiplatelet agent reversal]]

==References==
<references/>

[[Category:Pharmacology]]