View source for Template:Cholecystitis Antibiotics

''Most often isolated organisms are [[Escherichia coli]], [[Klebsiella pneumonia]], and [[anaerobes]], especially [[Bacteroides fragilis]]''

====Uncomplicated====
''Pathogenicity of [[Enterococci]] remains unclear and specific coverage is not routinely suggested for community-acquired infections''<ref name="WSES 2016">Ansaloni L, et al. 2016 WSES guidelines on acute calculous cholecystitis. World Journal of Surgery. (2016) 11:25. DOI 10.1186/s13017-016-0082-5</ref>
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Ertapenem|dose=1g IV once daily|context=Uncomplicated}} OR
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Metronidazole|dose=500mg IV q8hrs|context=Uncomplicated}} PLUS
**{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Ciprofloxacin|dose=400mg IV q12 hrs|context=Uncomplicated}} OR
**{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Levofloxacin|dose=750mg IV q24hrs|context=Uncomplicated}} OR
**{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Ceftriaxone|dose=1g IV q24hrs|context=Uncomplicated}}

====Complicated or Healthcare Associated====
''Examples of complication include severe [[sepsis]] or hemodynamic instability''
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Vancomycin|dose=15-20mg/kg|context=Complicated/Healthcare Associated}} PLUS any of the following options

'''Options:'''
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Metronidazole|dose=500mg IV q8hrs|context=Complicated}} PLUS {{AntibioticDose|disease=Acute calculous cholecystitis|drug=Ciprofloxacin|dose=400mg IV q12hrs|context=Complicated}}
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Piperacillin/Tazobactam|dose=4.5g IV q8hrs|context=Complicated}}
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Imipenem/Cilastatin|dose=500mg IV q6hrs|context=Complicated}}
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Doripenem|dose=500mg IV q8hrs|context=Complicated}}
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Meropenem|dose=1g IV q8hrs|context=Complicated}}

====Pediatric====
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Ceftriaxone|dose=50-75mg/kg IV daily (max 2g)|context=Pediatric|population=Pediatric}} + {{AntibioticDose|disease=Acute calculous cholecystitis|drug=Metronidazole|dose=7.5mg/kg IV q8hrs (max 500mg)|context=Pediatric|population=Pediatric}} '''OR'''
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Piperacillin/Tazobactam|dose=80-100mg/kg IV q6-8hrs (max 4.5g)|context=Pediatric|population=Pediatric}} '''OR'''
*{{AntibioticDose|disease=Acute calculous cholecystitis|drug=Meropenem|dose=20mg/kg IV q8hrs (max 1g)|context=Pediatric Complicated|population=Pediatric}}