View source for Streptomycin

==General==
*Type: [[Is DrugClass::Aminoglycoside]]
*Dosage Forms: 
**IM

==Adult Dosing==

===Infections, Bacterial===
*1-2 g/day IM divided q6-12h
**Max: 2 g/day; Info: adjust dose based on serum levels
**Renal dosing
***Creatinine Clearance 50-80: give q24h
***Creatinine Clearance 10-50: give q24-72h
***Creatinine Clearance <10: give q72-96h





===Indications by Disease===
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==Pediatric Dosing==

===Infections, Bacterial===
*20-40mg/kg IM q24h
**Alternative: 20-40mg/kg IM 2x/wk
**Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
**Renal dosing
***Creatinine Clearance 50-80: 7.5mg/kg give q24h
***Creatinine Clearance 10-50: 7.5mg/kg give q24-72h
***Creatinine Clearance <10: 7.5mg/kg give q72-96h





===Indications by Disease===
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 |?Has Dose=Dose
 |?Has Context=Context
 |format=table
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==Special Populations==
*[[Pregnancy Rating]]: D
*Lactation: Probably Safe
*Monitoring parameters:
**BUN/creatinine at baseline, then periodically.
**Serum drug levels
**Urinanalysis
**Audiometry for high risk patients

==Contraindications / Cautions==

*Contraindicated:
**BCG live intravesical
**[[Cidofovir]]
**[[Streptozocin]]

*caution if hypersensitivity to sulfites
*caution if impaired vestibular function
*caution if impaired auditory function
*caution if concurrent ototoxic agents
*caution if concurrent neurotoxic agents
*caution if neuromuscular disease
*caution if renal impairment
*caution if dehydration
*caution if concurrent nephrotoxic agent use
*caution if electrolyte abnormalities
*caution if prolonged use
*caution in neonates or infants
*caution in elderly patients

==Adverse Reactions==

===Serious===
*Ototoxicity, auditory & vestibular
*Neurotoxicity
*Neuromuscular blockade
*Nephrotoxicity
*Anemia, hemolytic
*Pancytopenia
*[[Thrombocytopenia]]
*[[Anaphylaxis]]
*Angioedema
*Hypersensitivity reaction
*Exfoliative dermatitis
*Superinfection

===Common===
*[[Nausea and vomiting]]
*[[Vertigo]]
*Paresthesia, facial
*[[Rash]]
*[[Fever]]
*[[Urticaria]]
*[[Angioedema]]
*Eosinophilia
*Deafness
*Exfoliative dermatitis
*[[Anaphylaxis]]
*Azotemia
*Leukopenia
*Thrombocytopenia
*Pancytopenia
*[[Anemia]], hemolytic
*muscle weakness
*Amblyopia
*Injection site reaction

==Pharmacology==
*Half-life: 5 hours
*Metabolism: Unknown; CYP450
*Excretion: Urine
*Mechanism of Action: Bactericidal (binds to 30S ribosomal subunit, inhibiting protein synthesis)

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>
Epocrates

[[Category:Pharmacology]]
[[Category:ID]]