View source for Sodium phenylacetate/sodium benzoate

==Administration==
*Type: 
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names: Ammunol

==Adult Dosing==
*5.5g/m2 over 90-120min

==Pediatric Dosing==
===[[Inborn errors of metabolism|Hyperammonemia]]===
*<20kg: 250mg/kg in D10 over 90min; then 250mg/kg/d infusion
*>20kg: 5.5g/m2 over 90-120min

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Pregnancy Category C

===Lactation risk===
*Unknown risk

===Renal Dosing===
*Adult: Monitor closely
*Pediatric: Monitor closely

===Hepatic Dosing===
*Adult: caution with use
*Pediatric: caution with use 

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Hypokalemia
*Fluid overload
*Tissue damage with extravasation from peripheral IV
*Neurotoxicity, seizure, coma
*Hyperventilation with metabolic acidosis (similar to salicylate toxicity)

===Common===
*Vomiting, hyperglycemia, hypokalemia, convulsions, and mental impairment.

==Pharmacology==
*Half-life: 
*Metabolism: 
*Excretion: 

==Mechanism of Action==


==Comments==


==See Also==
*[[Inborn errors of metabolism]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Pediatrics]]