View source for Meloxicam

==Administration==
*Type: [[NSAID]]
*Dosage Forms: 7.5, 15mg
*Routes of Administration: PO
*Common Trade Names: Mobic, Vivlodex

==Adult Dosing==
===[[Osteoarthritis]]===
*7.5-15mg PO QD
*Max 15mg/day

===[[Rheumatoid arthritis]]===
*7.5-15mg PO QD
*Max 15mg/day

==Pediatric Dosing==
===[[Juvenile idiopathic arthritis]](>60kg)===
*7.5mg PO QD
*Max 7.5mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C, category D if >30wk gestation
*[[Lactation risk categories|Lactation risk]]: safety unknown, inadequate literature available to assess risk

===Renal Dosing===
*Adult:
**mild-mod impairment: no adjustment
**CrCl <15: avoid use
**HD: max 7.5mg/day

*Pediatric: see Adult dosing

===Hepatic Dosing===
*Adult:
**Child-Pugh Class A or B: no adjustment
**Child-Pugh Class: not defined

*Pediatric: see Adult Dosing

==Contraindications==
*Allergy to class/drug
*ASA or NSAID-induced asthma or urticaria
*caution if:
**renal impairment, dehydration, elderly or debilitated
**history of GI bleed or ulcers, alcohol use, or coagulopathy
**hepatic impairment
**asthma
**cardiovascular disease (or high risk of), including CABG surgery periop use, recent MI, CHF, HTN, smoker
**fluid retention
**PKU
**prolonged use

==Adverse Reactions==
'''Serious'''
*GI bleed, ulcer, perforation
*blood dyscrasias, prolonged bleeding time, anemia
*nephrotoxicity, renal papillary necrosis
*MI, stroke, thromboembolism, HTN, CHF
*hepatotoxicity, hepatic necrosis, pancreatitis
*bronchospasm
*exfoliative dermatitis, SJS/TEN

'''Common'''
*dyspepsia, nausea/vomiting, abdominal pain, diarrhea, constipation, flatulence
*headache, dizziness, drowsiness, tinnitus
*dizziness
*rash, pruritus, urticaria, photosensitivity
*fluid retention, peripheral edema
*ecchymosis
*elevated creatinine, ALT/AST
*sinusitis
*vomiting (peds)
*headache (peds)
*fever (peds)
*delayed ovulation

==Pharmacology==
*Half-life: 15-20 hours
*Metabolism: liver extensively; CYP450 (2C9, 3A4 substrate)
*Excretion: urine (0.2% unchanged); feces (1.6% unchanged)
*Mechanism of Action: exact MOA unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

==Comments==

==See Also==
*[[NSAID]]
*[[NSAID toxicity]]

==References==
<references/>
[[Category:Pharmacology]]