View source for Itraconazole

==Administration==
*Type: [[Antifungal]]
*Dosage Forms: Capsule, solution (for oropharyngeal/esophageal candida)
*Routes of Administration:
*Common Trade Names: Sporanox, Sporaz, Orungal

==Adult Dosing==
*200mg PO 1-4 times per day


===Indications by Disease===
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==Pediatric Dosing==
*> 5y: 2.5-10mg/kg 2-3 times per day

===Indications by Disease===
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==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
===Renal Dosing===
*Adult: No adjustment
*Pediatric:
===Hepatic Dosing===
*Adult: No adjustment
*Pediatric:

==Contraindications==
*Allergy to class/drug
*Concomitant use of CYP3A4 substrates (e.g. ergots, lurasidone, methadone, oral midazolam, simvastatin, ticagrelor, and triazolam)
*Ventricular dysfunction (relative)
==Adverse Reactions==
===Serious===
*[[CHF]], pulmonary edema
*Hepatotoxicity
*SJS/TEN
*[[Pancreatitis]]
===Common===
*Nausea/vomiting, diarrhea, abdominal pain
*Headache, dizziness
*Edema
*Pruritus, rash
*URI symptoms

==Pharmacology==
*Half-life: 32-96h
*Metabolism: Hepatic, [[P450]] CYP3A4
*Excretion: Urine, Feces

==Mechanism of Action==
*Inhibits synthesis of ergosterol (fungal cell membrane component) 
==Comments==

==See Also==
*[[Antifungals]]
*[[Fungal infections]]

==References==
<references/>
[[Category:Pharmacology]]
[[Category:ID]]