View source for Intravenous immunoglobulin

==Administration==
*Type: Immunologic agent
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names: Gammagard, Gammar-IV, Gamimune-N, Camunex, Carimune/Panglobulin, Iveegam, Polygam S/D, Sandoglobulin, Venoglobulin, KIOVIG
''Note: components of each brand vary''

==Adult Dosing==
''Varies depending on formulation''

==Pediatric Dosing==
''Varies depending on formulation''

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk minimal
*Renal dosing: administer at minimum infusion rate possible
*Hepatic dosing: no adjustment

==Indications==
*FDA-approved indications:
**[[Immune thrombocytopenic purpura]]
**[[Kawasaki]]
**Common variable immunodeficiency, primary immunodeficiency associated with humoral imunodeficiency
**Kidney transplant with high antibody recipient or ABO incompatible donor
*Chronic B-cell leukemia, [[stem cell transplantation]]
*Off-label indications
**[[TTP]], [[HUS]]
**[[Aplastic anemia]], autoimmune [[hemolytic anemia]]
**[[Myasthenia gravis]], [[Lambert-Eaton myasthenic syndrome]]
**[[Guillain-Barre syndrome]]
**[[Anti-NMDA receptor encephalitis]]
**Severe [[Pyoderma]], severe [[Pemphigus vulgaris]]
**Acute [[GVHD]]
**Immune-mediated [[neutropenia]]
**Recurrent [[C. diff]]
==Contraindications==
*Allergy to class/drug
*Hereditary intolerance to sucrose or fructose
*Hyperprolinemia 
*IgA deficiency with antibodies
**all IVIG contain trace IgA
**Gammagard and Polygram have the least

==Adverse Reactions==
===Serious===
*MI, chest pain
*Tachycardia
*Hemolytic anemia
*Thrombosis, PE
*Acute renal failure
*Hyponatremia
*Aseptic meningitis
*Transfusion related acute lung injury
===Common===
*Hypertension, hypotension
*Peripheral edema
*Pruritus, rash, injection site reaction
*Hyperthermia
*Nausea, vomiting, diarrhea, abdominal pain
*[[Aphthous ulcer]]
*Arthralgia, myalgia, backache, headache
*Dizziness, fatigue
*Otalgia
*Asthma, nasal congestion, wheezing, pharyngitis
*Fever, rigors, shivering
*Infusion reaction

==Pharmacology==
*Half-life: 5-37 days
*Metabolism: 
*Excretion: 

==Mechanism of Action==
*Interference with Fc receptors on the cells of the reticuloendothelial system for autoimmune cytopenias and ITP

==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

{{#ask:[[Has DrugName::IVIG]]
 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=table
 |headers=plain
 |mainlabel=-
 |sort=Has Indication
 |limit=50
}}


==See Also==

==References==
<references/>
[[Category:Pharmacology]]