View source for Esmolol

==General==
*Type: [[Beta blockers]] 
*Dosage Forms:
*Common Trade Names: Brevibloc

==Adult Dosing==
*Loading dose = 500mcg/kg bolus over 1min
**Follow this with infusion at 50mcg/kg/min for 4min
***If no response give another 500 bolus, increased infusion to 100
***If no response give another 500 bolus, increased infusion to 200

*Symptomatic AAA (controversial)
**500mcg/kg bolus
**Infusion of 50-200mcg/kg/min titrated to goal SBP

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*Lactation: Unknown if excreted in breast milk
*Renal Dosing
**Adult: No adjustment required
*Hepatic Dosing
**Adult: No adjustment required

==Contraindications==
*Allergy to class/drug
*Cardiogenic shock
*2nd or 3rd AV block

==Indications==
*Supraventricular arrhythmias
*Heart rate and blood pressure control in Symptomatic Aortic Aneurysm (titrate to HR <60 bmp)
*Off label use: refractory [[VF]]

==Adverse Reactions==
*Hypotension
*Bronchospasm

==Pharmacology==
*Half-life: Adults - 9min Children 18mo-16yrs 2.7-4.8min
*Metabolism: Red Blood Cell Esterase
*Excretion: Renal
*Mechanism of Action:  Class II - Short-acting Beta1 blocker
*Onset of action = 1-4min 
*Duration of action = <30min


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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 |?Has Indication=Indication
 |?Has Dose=Dose
 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
 |format=table
 |headers=plain
 |mainlabel=-
 |sort=Has Indication
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==See Also==
*[[Beta-blockers]]
*[[Beta-blocker toxicity]]
*[[Antiarrhythmics]]
*[[Antihypertensive medications]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Cardiology]]
[[Category:Critical Care]]