View source for Erythromycin

==General==
*Type: [[Is DrugClass::Macrolide]]
*Dosage Forms: PO, IV, topical
*Common Trade Names: 

==Adult Dosing==
*250-500mg PO q6h



===Indications by Disease===
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 |?Treats disease=Disease
 |?Has Dose=Dose
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==Pediatric Dosing==
*Mild-moderate infections: 30-50 mg/kg/day PO divided q6-8hr  
*Severe infection: 60-100 mg/kg/day PO divided q6-8hr


===Indications by Disease===
{{#ask: [[Has DrugName::Erythromycin]] [[Has Population::Pediatric]]
 |?Treats disease=Disease
 |?Has Dose=Dose
 |?Has Context=Context
 |format=table
 |limit=50
 |mainlabel=-
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==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B 
*[[Lactation risk categories|Lactation risk]]: AAP categorizes as compatible with breastfeeding
*Renal Dosing: No adjustment
*Hepatic Dosing: Use caution

==Contraindications==
*Allergy to class/drug
* QT prolongation

==Adverse Reactions==
===Serious===
*Torsades, ventricular dysrhythmias
*Pseudomembranous colitis
*Hypertrophic pyloric stenosis
*Seizures

===Common===
* nausea/vomiting
* diarrhea 
* urticaria
* transaminitis 
* urticarial rash

==Pharmacology==
*Half-life: 2 hours
*Metabolism: Liver
*Excretion: Bile/Renal
*Mechanism of Action: Binds to 50S ribosomal unit → inhibiting protein synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||I
|-
| ||[[Strep. Pneumoniae]]||I
|-
| ||[[Viridans strep]]||X1
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||I
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||I
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||'''S'''
|-
| Gram Negatives||[[N. gonorrhoeae]]||I
|-
| ||[[N. meningitidis]]||X2
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||I
|-
| ||[[E. coli]]||R
|-
| ||[[Klebsiella]] sp||R
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||X1
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||R
|-
| ||[[Shigella]] sp||R
|-
| ||[[Proteus mirabilis]]||X1
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||X1
|-
| ||[[Morganella sp.]]||X1
|-
| ||[[Citrobacter freundii]]||X1
|-
| ||[[Citrobacter diversus]]||X1
|-
| ||[[Citrobacter sp.]]||X1
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||R
|-
| ||[[Legionella sp.]]||'''S'''
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||'''S'''
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||'''S'''
|-
| ||[[Mycoplasm pneumoniae]]||'''S'''
|-
| ||[[Rickettsia sp]]||I
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||'''S'''
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||R
|-
| ||[[Peptostreptococcus sp.]]||I
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>
[[Category:Pharmacology]]
[[Category:ID]]