View source for Dipyridamole

==Administration==
*Type: [[Antiplatelet]]
*Dosage Forms: Tablet 25mg, 50mg, 75mg; INJ
*Routes of Administration: Oral, IV
*Common Trade Names: Persantine

==Adult Dosing==
===Cardiac Stress Testing===
*0.142 mg/kg/min IV x4min
===[[Thromboembolism]] prevention adjunct for cardiac valve===
*75-100 mg PO qid
===[[Thromboembolism]] prevention===
*50=100 mg PO qid
===[[Angina]] prophylaxis===
*50 mg PO tid

==Pediatric Dosing==
===[[Thromboembolism]] prevention adjunct for cardiac valve===
*2-5 mg/kg/day PO divided tid
**Give with [[warfarin]] or [[aspirin]]

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Caution advised during pregnancy
*Risk of increased maternal bleeding during delivery

===Lactation risk===
*Caution advised while breastfeeding

===Renal Dosing===
*Adult: No adjustment
*Pediatric: No adjustment

===Hepatic Dosing===
*Adult: Not defined
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Hypotension]]
*Bronchospasm, IV use
*[[Myocardial infarction]], IV use
*[[Arrhythmia]], IV use

===Common===
*[[Angina]] exacerbation
*[[Dizziness]], [[Hypotension]], [[Nausea]], [[Headache]]
*[[Flushing]], [[Rash]]
*[[Vomiting]], [[Diarrhea]], [[Abdominal pain]]

==Pharmacology==
*Half-life: 10 hours
*Metabolism: Liver
*Excretion: Bile

==Mechanism of Action==
*Inhibits platelet adenosine uptake, reducing platelet aggregation
*Augments cGMP production, dilating coronary arteries

==Comments==


==See Also==
*[[Antiplatelet medications]]
*[[Antiplatelet agent reversal]]

==References==
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[[Category:Pharmacology]]