View source for Cefditoren

==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::cephalosporin]]
*Dosage Forms: tablet 
*Dosage Strengths: 200, 400mg
*Routes of Administration: PO
*Common Trade Names: Spectracef

==Adult Dosing==
===Chronic [[Bronchitis]], Acute bacterial exacerbation===
*400 mg PO bid x10 days
===[[Pneumonia]], community-acquired===
*400 mg PO bid for at least 5 days
**May D/C after five days if afebrile x48-72 hours
===[[Pharyngitis]]/Tonsillitis, streptococcal===
*200mg PO bid x10 days
===Skin infection===
*200 mg PO bid x10 days

==Pediatric Dosing==
===12+ yo, Chronic [[Bronchitis]], Acute bacterial exacerbation===
*400 mg PO bid x10 days
===12+ yo, [[Pneumonia]], community-acquired===
*400 mg PO bid x14 days
===12+ yo, [[Pharyngitis]]/Tonsillitis, streptococcal===
*200mg PO bid x10 days
===12+ yo, Skin infection===
*200 mg PO bid x10 days

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B; May use during pregnancy
*Lactation: May use while breastfeeding
*Renal Dosing
**Adult
***CrCl 30-49: Max 200mg bid
***CrCl <30:   Max 200mg qd
***ESRD/HD:    Not defined
**Pediatric
***CrCl 30-49: Max 200mg bid
***CrCl <30:   Max 200mg qd
***ESRD/HD:    Not defined
*Hepatic Dosing
**Adult
***Child-Pugh Class A or B: No adjusment
***Child-Pugh Class C: Not defined
**Pediatric
***Child-Pugh Class A or B: No adjusment
***Child-Pugh Class C: Not defined

==Contraindications==
*Allergy to class/drug
*Hypersensitivity to milk proteins
*Carnitine deficiency
*Caution:
**Hypersensitivity to PCN
**Renal impairment
**Decreased muscle mass
**Recent abx-associated colitis

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*Serum-sickness like reaction
*[[Stevens-Johnson syndrome]]
*[[Erythema multiforme]]
*[[Toxic epidermal necrolysis]]
*[[Leukopenia]]
*[[Neutropenia]]
*[[Thrombocytopenia]]
*[[Anemia]], hemolytic
*[[Seizure]]
*Nephrotoxicity
*Cholestatic [[jaundice]]
*C. difficle-associated diarrhea
*Super infection
*Carnitine deficiency (long-term use)

===Common===
*[[Diarrhea]]
*[[Nausea]]
*[[Headache]]
*[[Abdominal pain]]
*Candidiasis, vulvovaginal
*Dyspepsia

==Pharmacology==
*Half-life: 1.6h; 4.7h in severe renal impairment
*Metabolism: Minimal
*Excretion: Urine primarily
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||X1
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||X1
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||X1
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||I
|-
| ||[[Providencia sp.]]||X1
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||X1
|-
| ||[[Citrobacter sp.]]||'''S'''
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||X1
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||X1
|-
| ||[[Stenotrophomonas maltophilia]]||X1
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||X1
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]