View source for Itraconazole

==Administration==
*Type: Antifungal
*Dosage Forms: Capsule, solution (for oropharyngeal/esophageal candida)
*Routes of Administration:
*Common Trade Names: 

==Adult Dosing==
*200mg PO 1-4 times per day

==Pediatric Dosing==
* > 5y: 2.5-10mg/kg 2-3 times per day
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
===Renal Dosing===
*Adult: No adjustment
*Pediatric:
===Hepatic Dosing===
*Adult: No adjustment
*Pediatric:

==Contraindications==
*Allergy to class/drug
*Concomitant use of CYP3A4 substrates (e.g. ergots, lurasidone, methadone, oral midazolam, simvastatin, ticagrelor, and triazolam)
*Ventricular dysfunction (relative)
==Adverse Reactions==
===Serious===
*CHF, pulmonary edema
*Hepatotoxicity
*SJS/TEN
*Pancreatitis
===Common===
*Nausea/vomiting, diarrhea, abdominal pain
*Headache, dizziness
*Edema
*Pruritus, rash
*URI symptoms

==Pharmacology==
*Half-life: 32-96h
*Metabolism: Hepatic, P450 CYP3A4
*Excretion: 

==Mechanism of Action==
*Inhibits synthesis of ergosterol (fungal cell membrane component) 
==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]