View source for Dapsone

==Administration==
*Type: Antibiotic
*Dosage Forms: 25,100
*Routes of Administration: Oral

==Adult Dosing==
*Hansen disease (leprosy)
**paucibacillary: 100 mg PO qd x6mo
***Use w/ rifampin
**multibacillary: 100 mg PO qd x12mo
***Use w/ rifampin, clofazimine

*Dermatitis herpetiformis: 50 mg PO qd

*PCP prophylaxis: 100 mg/day PO divided qd-bid
**Off label use

*PCP tx: 100 mg PO qd x21 days
**Not 1st-line agent; use w/ trimethoprim
**Off label use

*Malaria suppression: 100 mg PO qwk
**Use w/ pyrimethamine
**Off label use

*Toxoplasmosis prophylaxis: 50 mg PO qd
**Off label use

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Probably unsafe
===Renal Dosing===
*No adjustment
===Hepatic Dosing===
*Caution advised with hepatic impairment
*CBC qwk x4, qmo x6, then q6mo thereafter
*LFTs at baseline, then periodically

==Contraindications==
*Allergy to class/drug
*caution if renal or hepatic impairment
*caution if impaired cardiovascular function

==Adverse Reactions==
===Serious===
*anemia, hemolytic
*aplastic anemia
*agranulocytosis
*exfoliative dermatitis
*erythema multiforme
*toxic epidermal necrolysis
===Common===
*fever
*myalgia
*headache
*rigors
*fatigue
*malaise
*dizziness

==Pharmacology==
*Half-life: 28 hrs
*Metabolism: Liver, CYP450
*Excretion: Urine

==Mechanism of Action==

==Comments==

==See Also==

==References==
<Epocrates, UpToDate>
[[Category:Pharmacology]]