View source for Icatibant

==General==
*Type: Bradykinin receptor antagonist
*Dosage Forms: 30mg
*Routes of Administration: Subcutaneous
*Common Trade Names: Firazyr

==Adult Dosing==
===[[Hereditary angioedema]]===
*30mg subcutaneous x 1
**May repeat q6h if inadequate response/symptoms recur
*Max 90mg/24 hours

==Pediatric Dosing==
not available (8/2015)
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: safety unknown
*Renal Dosing
*Hepatic Dosing

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Caution if acute MI
*Caution if unstable angina
*Caution if recent stroke
===Common===
*Injection site reaction
*Dizziness
*Fever
*Increased LFTs

==Pharmacology==
*Half-life: 1.4h
*Metabolism: Proteolytic degradation
*Excretion: Urine 10% unchanged
*Mechanism of Action: selectively antagonizes bradykinin B2 receptor

==Comments==
*NEJM article 1/2015 randomized 27 people with ACEi induced angioedema to icatibant vs std therapy (Prednisone 500mg + Clemastine 2mg) looking at time to resolution.
RESULTS- significantly shorter (8 hrs vs 27.1 hrs) in icatibant group. 
*Cost according to Goodrx= $9,000/dose (on 8/7/2015)


==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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 |?Has Context=Context
 |?Has Route=Route
 |?Has Population=Population
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==See Also==
*[[Angioedema (Upper Airway)]]

==References==
<references/>
[[Category:Pharmacology]]