View source for Succimer

==Administration==
*Type: [[Antidote]]
*Dosage Forms: 
*Routes of Administration: Oral
*Common Trade Names: 

==Adult Dosing==
*[[Lead poisoning]]: 10 to 30 mg/kg/day for 5 days
==Pediatric Dosing==
''Safety/efficacy not established in patients <12mo''
*Lead poisoning, level >45 mcg/dL: 10 mg/kg or 350 mg/m(2) q8h for 5 days, then q12 h for 14 days
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: administer with caution, ensure adequate hydration
*Hepatic dosing: no adjustment, monitor LFTs closely

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Neutropenia
===Common===
*Rash
*Nausea/vomiting, diarrhea, decreased appetite
*Elevated transaminases

==Pharmacology==
*Half-life: 48h
*Metabolism: 
*Excretion: Renal 25%

==Mechanism of Action==
*Forms stable, water-soluble complexes with lead, leading to increased urinary excretion

==Comments==

==See Also==
*[[Antidotes]]
*[[Lead toxicity]]
*[[EDTA]], [[Dimercaprol]]
==References==
<references/>
[[Category:Pharmacology]]