Tinidazole
General
- Type: Antiparasitic
- Dosage Forms: 250, 500
- Routes of Administration: PO
- Common Trade Names: Tindamax
Adult Dosing
- Give with food
Intestinal Amebiasis
- 2000mg PO daily x 3 days
Amebic liver abscess
- 2000mg PO daily x 3-5 days
Giardiasis
- 2000mg PO x 1
Trichamoniasis
- 2000mg PO x 1
- Treat partner to avoid re-exposure
Bacterial vaginosis
- 2000mg PO daily x 2 days OR 1000mg PO daily x 5 days
- Non-pregnant women only
Urethritis
- 2000mg PO x 1
- Give with azithromycin if not treated with azithromycin previously
Pediatric Dosing
- Approved for age >3 years
- Give with food
Intestinal Amebiasis
- 50mg/kg PO daily x 3 days
- Max 2000mg/dose
Amebic liver abscess
- 50mg/kg PO daily x 3-5 days
- Max 2000mg/dose
Giardiasis
- 50mg/kg PO x 1
- Max 2000mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unsafe
- Renal Dosing
- Adult: Adjust dose amount; 50% usual dose as supplement if on HD
- Pediatric: Adjust dose amount; 50% usual dose as supplement if on HD
- Hepatic Dosing
- Adult: No defined dose adjustment but can cause hepatic impairment. Use with caution.
- Pediatric: No defined dose adjustment but can cause hepatic impairment. Use with caution.
Contraindications
- Allergy to class/drug
- Pregnancy, 1st trimester
- Breastfeeding up to 72 hours after treatment
- Alcohol use up to 72 hours after treatment
- Hepatic impairment
- Blood dyscrasia
- CNS disorder
Adverse Reactions
Serious
- Seizure
- Peripheral neuropathy
- Thrombocytopenia
- Hypersensitivity reaction
- Angioedema
- Stevens-Johnson syndrome
- Erythema multiforme
- Bronchospasm
Common
- nausea and vomiting
- Anorexia
- Metallic taste
- Fatigue/weakness
- Candidiasis
- Flatulence
- UTI
- Pelvic pain
- Vulvovaginal discomfort
- Vaginal odor
- Menorrhagia
- URI
Pharmacology
- Half-life: 12-14 hours
- Metabolism: Liver; CYP450
- Excretion: Urine 20-25%, feces 12%
- Mechanism of Action: Bactericidal; inhibits DNA synthesis
Comments
- Black box warning: Carcinogenic risk
See Also
References
- Epocrates