The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Background
- External compression by extrinsic malignant mass causes majority of cases
- Thrombus in SVC from indwelling catheter/pacemaker is increasingly more common as cause
- Other causes include benign tumors, aortic aneurysm, infections, and fibrosing mediastinitis[1]
- Rarely constitutes an emergency
Risk Factors
- Lung Cancer
- Lymphoma
- Indwelling vascular catheters (increasing incidence)
- Thrombophilia
- Goiter
- TB
- Radiation
- Pericardial constriction
Clinical Features
SVC syndrome with classic symptoms, including obvious face, neck, and upper trunk swelling.
Differential Diagnosis
Related to Local Tumor Effects
Related to Biochemical Derangement
Related to Hematologic Derangement
Related to Therapy
Evaluation
CT chest showing right lung tumor compressing SVC
- CT with IV contrast
- Recommended imaging modality (assesses patency of the SVC, evaluate etiology mass vs. thrombus)
- CXR
- Shows mediastinal mass or parenchymal lung mass (10% of patients)
Management
- Elevate head of bed
- Assess for and treat elevated intracranial pressure
- Use IVs placed in lower extremities to avoid further SVC venous congestion[2]
- Corticosteroids and loop diuretics have questionable efficacy and should be held until ordered by admitting team[3]
- Intravascular stent, consult IR
- If malignancy
- Mediastinal radiation, consult oncology/radiation oncology
- If thrombus
Disposition
- Admit to ICU, with plan for airway monitoring and tissue biopsy
References
- ↑ Nickloes TA, Lopez Rowe V, Kallab AM, Dunlap AB (28 March 2018). "Superior Vena Cava Syndrome". Medscape
- ↑ Chaudhary K, Gupta A, Wadhawan S, Jain D, Bhadoria P. Anesthetic management of superior vena cava syndrome due to anterior mediastinal mass. J Anaesthesiol Clin Pharmacol [serial online] 2012 [cited 2016 Jul 19];28:242-6. Available from: http://www.joacp.org/text.asp?2012/28/2/242/94910.
- ↑ McCurdy M et al. Oncologic emergencies, part I: spinal cord compression, superior vena cava syndrome, and pericardial effusion. Emergency Medicine Practice. 2010; 12(2):7-10.