Calcium gluconate
Revision as of 19:50, 19 July 2016 by Neil.m.young (talk | contribs) (Text replacement - "5 mg" to "5mg")
General
- Type:
- Dosage Forms: IV/PO
- Common Trade Names: Calcium Gluconate
Adult Dosing
- Calcium Supplementation
- 19-50 years old: 1000mg/day PO (divided q8-12hr)
- >50 years old: 1200mg/day PO (divided q8-12hr)
- Pregnant or breastfeeding patient: 1000mg/day PO (divided q8-12hr)
- Hypocalcemia
- Mild (Calcium 1-1.2 mmol/L)
- 1-3 g/day PO in divided doses
- 1-2 g IV over 2 hours
- Severe (Calcium < 1 mmol/L)
- without seizure or tetany: 0.5mg/kg/hr IV, may be increased to 2mg/kg/hr
- Hypocalcemic tetany:
- 100-300mg elemental calcium (~3g calcium gluconate) IV over 5-10 min
- Followed by continuous IV infusion at 0.5mg/kg/hr
- Mild (Calcium 1-1.2 mmol/L)
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation risk: Use with caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Hypersensitivity
- Hypercalcemia
- Digoxin poisoning
Adverse Reactions
- Frequency not defined
- Bradycardia
- Constipation
- Headache
Pharmacology
- Half-life:
- Metabolism:
- Absorption requires Vitamin D
- Absorption is increased with acidic condition; thus, administer 1-2 hr after meals
- ~45% protein bound (primarily to albumin)
- Excretion: Feces (80%), Urine (20%)
- Mechanism of Action: Bone mineral component; cofactor in enzymatic reactions, essential for neurotrasmission, muscle contraction, and many signal transduction pathways.