Blood products

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Cryoprecipitate Transfusion

Features

  1. Cold insoluble protein fraction of FFP
  2. Contains: fibrinogen, vWF, and factor VIII
  3. 1 bag (10ml) has 50-500 units of factor 8 activity

Indications

  1. Bleeding with fibrinogen level of <100 milligrams/dL
  2. Dysfibrinogenemia
  3. Bleeding in vWD that is unresponsive to DDAVP and Factor VIII is unavailable (can also use Humate-P, FFP doesn't work well)

Dose

  1. 1 unit/5kg (usually 10 units are given at a time)
    1. Will raise fibrinogen level by 75

Humate-P

Features

  1. Contains: vWF and factor VIII

Indications

  1. Hemophilia A (can also use factor VIII, FFP doesn't work well)
  2. vWD that is unresponsive to DDAVP (can also use cryo, FFP doesn't work well)

Dose

Depends on condition and severity of bleeding

See Also

Source

Tintinalli